Skin blister test
The skin blister test (or blister test , cantharidin test ) is an experimental method for investigating the distribution of a substance ( active ingredient or drug ) in the interstitial fluid . In pharmacokinetics, it is used to determine the ability of a substance to penetrate tissue when it is applied to the skin or its concentration in the interstitium .
When blister test, a highly irritating substance (usually cantharidin ) of the skin applied, thereby resulting in a liquid-filled blister (engl. Blister forms). For example, the concentration of an administered drug in the liquid (an exudate ) can be determined.
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- JF Hoogkamer et al .: Pharmacodynamic activity of a cephalosporin, Ro 40-6890, in human skin blister fluid: antibiotic activity in concert with host defense mechanisms . Antimicrob Agents Chemother . (1993) 37 (12): pp. 2622-2627 PMID 8109926