Interstitium (anatomy)

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As interstitium ( lat. - Anat. ;, Gap ') or stroma ( Greek. -Anat.) Is in the histology which the parenchymatous organs (supportive) and untergliedernde by withdrawing intermediate tissue , respectively. It is mostly a matter of connective and supporting tissue , more rarely epithelial tissue or muscle cells . Occasionally, the term 'interstitium' is also used for the space between cells .


The interstitium of organs that are exposed to higher levels of movement (the submucosa of the digestive tract , the bladder, the skin , the peri- bronchial and peri- arterial connective tissue) are crisscrossed with comparatively thick bundles of collagen fibers , which help them to stretch against mechanical stress , Shear and compression are stabilized. The collagen fibers are covered on one side with fibroblast-like cells, on the other side surrounded by the tissue fluid .

The supply pathways ( blood vessels , nerves ) of the organ run in the interstitium . It subdivides the corresponding organ into lobes (lat. Lobi ), lobes (lat. Lobuli ) or complexes . The cells of the interstitium are not specific for the organ. The intercellular spaces are filled by the extracellular matrix and tissue fluid.

For an examination of the fluid-filled spaces by confocal laser endomicroscopy , the surrounding tissues are frozen with the fluid before fixation , otherwise the fluid will leak, the cell space collapses and the tissues adhere to one another.


  • Horst Erich König, Hans-Georg Liebich: Anatomy of domestic mammals: textbook and color atlas for study and practice . Schattauer Verlag, 2012, ISBN 978-3-7945-2832-5 , p. 6.

Web links

Wiktionary: Interstitium  - explanations of meanings, word origins, synonyms, translations

Individual evidence

  1. Günther Bringezu: Textbook of decongestive therapy. Springer-Verlag, 2014, ISBN 978-3-642-54922-9 , p. 19.
  2. a b c Petros C. Benias, Rebecca G. Wells, Bridget Sackey-Aboagye, Heather Klavan, Jason Reidy, Darren Buonocore, Markus Miranda, Susan Kornacki, Michael Wayne, David L. Carr-Locke, Neil D. Theise: Structure and Distribution of an Unrecognized Interstitium in Human Tissues. In: Scientific Reports. 8, 2018, doi: 10.1038 / s41598-018-23062-6 .