Holmes Syndrome

The Holmes syndrome or Holmes degeneration is a hereditary disorder characterized by cerebellar-related ataxia due to cerebellar - degeneration . It is counted among the ADCA .

Synonyms are:

• Systematized primarily progressive cerebellar degeneration
• Cerebello-olive atrophy

The name refers to the first description from 1907 by the British neurologist Gordon Morgan Holmes (1876-1965).

distribution

The inheritance is autosomal dominant .

Clinical manifestations

Diagnostic criteria are:

• Manifestation in middle to later adulthood
• Ataxia beginning on the legs and spreading towards the head
• Speech disorders
• Holding and intent tremors
• Decreased muscle tone
• Later, nystagmus

Individual evidence

1. ↑ ^{a b c} B. Leiber: The clinical syndromes. Syndromes, sequences and symptom complexes. Edited by G. Burg, J. Kunze, D. Pongratz, PG Scheurlen, A. Schinzel, J. Spranger. 7th edition. Urban & Schwarzenberg, 1990, ISBN 3-541-01727-9 .
2. ↑ GM Holmes: A form of familial degeneration of the cerebellum. In: Brain. Oxford 1907, 30, pp. 466-489.
3. ↑ Who named it

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !