Intrinsically unstructured proteins

Intrinsically unstructured proteins (also IUP , English : intrinsically unstructured protein ) are intrinsically disordered proteins with no defined three-dimensional structure . IUDs are only characterized by their lack of tertiary structure, whereas IDPs cover a wide spectrum of completely unstructured and partially structured states.

Due to the large number of charged and polar amino acids and the comparatively small number of hydrophobic residues, these proteins are able to adopt a defined structure when they interact with other proteins. IUDs are primarily involved in signal transduction and the regulation of reaction mechanisms.

The naming of the protein groups happened independently of each other. The designation IUP was introduced in 1999 and IDP in 2001.

literature

Jeremy M. Berg, Lubert Stryer , John L. Tymoczko: Stryer Biochemistry. Springer-Verlag, Berlin, Heidelberg 2014, ISBN 978-3-8274-2989-6 .

Individual evidence

^ PE Wright, HJ Dyson: Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm. In: Journal of molecular biology. Volume 293, Number 2, October 1999, pp. 321-331, doi : 10.1006 / jmbi.1999.3110 , PMID 10550212 (review).
↑ AK Dunker, JD Lawson, CJ Brown, RM Williams, P. Romero, JS Oh, CJ Oldfield, AM Campen, CM Ratliff, KW Hipps, J. Ausio, MS Nissen, R. Reeves, C. Kang, CR Kissinger, RW Bailey, MD Griswold, W. Chiu, EC Garner, Z. Obradovic: Intrinsically disordered protein. In: Journal of molecular graphics & modeling. Volume 19, Number 1, 2001, pp. 26-59, PMID 11381529 (review).

[PMID10550212-1] PE Wright, HJ Dyson: Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm. In: Journal of molecular biology. Volume 293, Number 2, October 1999, pp. 321-331, doi : 10.1006 / jmbi.1999.3110 , PMID 10550212 (review).

[PMID11381529-2] AK Dunker, JD Lawson, CJ Brown, RM Williams, P. Romero, JS Oh, CJ Oldfield, AM Campen, CM Ratliff, KW Hipps, J. Ausio, MS Nissen, R. Reeves, C. Kang, CR Kissinger, RW Bailey, MD Griswold, W. Chiu, EC Garner, Z. Obradovic: Intrinsically disordered protein. In: Journal of molecular graphics & modeling. Volume 19, Number 1, 2001, pp. 26-59, PMID 11381529 (review).