James Otis
James Otis is the name of the following people:
- James Otis Sr. (1702–1778), American attorney
- James Otis Jr. (1725–1783), American lawyer and politician (Massachusetts)
- James Otis (Politician, 1826) (1826–1875), American politician, Mayor of San Francisco
- James Otis , writer name of James Otis Kaler (1848–1912), American journalist and writer
- James Otis (actor) (born 1943), American actor
- James C. Otis (1912-1993), American judge