MEST (Gen)

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In humans, the MEST gene codes for the MEST protein ( English mesoderm-specific transcript homolog protein ). An alternative name is "Paternally expressed gene 1 (PEG1)".

MEST is the first gene on chromosome 7 of humans to be recognized as genomically imprinted .

MEST codes for a member of the alpha / beta hydrolase family and has an isoform-specific character. The loss of imprint has been linked to different types of cancer and is believed to be due to a change in promoter . The encoded protein probably plays a role in the development of the organism. Three transcript variants encoding two different isoforms have been identified. A pseudogene was found on chromosome 6 of humans.

The MEST gene contains the DNA sequence for the microRNA -335 (-5p), a small RNA that has been recognized as an important regulator in the development of malignant tumors.

Individual evidence

  1. ↑ Y. Nishita, I. Yoshida, T. Sado, N. Takagi: Genomic imprinting and chromosomal localization of the human gene MEST. In: Genomics. 36 (3), 1997, pp. 539-542. doi: 10.1006 / geno.1996.0502
  2. ↑ Entrez Gene MEST mesoderm specific transcript homolog (mouse).
  3. ↑ S. Kobayashi, T. Kohda, N. Miyoshi, Y. Kuroiwa, K. Aisaka, O. Tsutsumi, T. Kaneko-Ishino, F. Ishino: Human PEG1 / MEST, an imprinted gene on chromosome 7. In: Hum Mol Genet . 6 (5), 1997, pp. 781-786.
  4. ↑ O. Dohi, K. Yasui, Y. Gen, H. Takada, M. Endo, K. Tsuji, C. Konishi, N. Yamada, H. Mitsuyoshi, N. Yagi, Y. Naito, S. Tanaka, S. Arii, T. Yoshikawa: Epigenetic silencing of miR-335 and its host gene MEST in hepatocellular carcinoma. In: International Journal of Oncology . 42 (2), Feb 2013, pp. 411-418. doi: 10.3892 / ijo.2012.1724 .