Hydrolases

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Hydrolases
Enzyme classification
EC, category 3.-.-.-
Response type hydrolysis
Substrate
Products
Occurrence
Parent taxon Creature

Hydrolases are enzymes which hydrolytically split esters , ethers , peptides , glycosides , acid anhydrides or CC bonds in a reversible reaction . They form the third group of the EC enzyme classification. Their representatives include peptidases , nucleases , phosphatases , glycosidases and esterases .

The catalyzed equilibrium is

classification

In the internationally recognized EC classification of enzymes, the hydrolases form group 3. Then hydrolases are further subdivided depending on which type of bond is split:

number binding Group name example
EC  3.1.-.- Ester bond Esterases Lipase

Nuclease

Phosphatase

Sulfatase

EC  3.2.-.- Glycoside bond Glycosylases Amylase

Glycosidases

EC  3.3.-.- Ether linkage
EC  3.4.-.- Peptide bond Peptidases Exopeptidase

Endopeptidase

EC  3.5.-.- CN bond (without peptide) Amidases Urease
EC  3.6.-.- Acid anhydride bond Pyrophosphatase
EC  3.7.-.- CC bond Kynureninase
EC  3.8.-.- Halogen bond
EC  3.9.-.- PN binding
EC  3.10.-.- SN bond
EC  3.11.-.- CP binding
EC  3.12.-.- SS binding
EC  3.13.-.- CS bond

Well-known examples

Other classes of enzymes

See also

Individual evidence

  1. ^ Albert Gossauer: Structure and reactivity of biomolecules , Verlag Helvetica Chimica Acta, Zurich, 2006, p. 450, ISBN 978-3-906390-29-1 .
  2. Overview of the hydrolase nomenclature (English, accessed on August 4, 2020)