Transferase
Transferases | ||
---|---|---|
Transaldolase ( EC 2.2.1.2 ) | ||
Enzyme classification | ||
EC, category | 2.-.-.- | |
Response type | Transfer of a functional group ( donor-acceptor principle ) | |
Substrate | ||
Products | ||
Occurrence | ||
Parent taxon | Creature |
Transferases (from Latin transferre , `` to carry over '') are enzymes of the second enzyme class according to the systematic nomenclature of the enzyme commission of the International Union of Biochemistry (IUB) and catalyze the transfer of a functional group X (e.g. a methyl group or phosphate group ) from a donor A. to an acceptor B :
The donor is often a coenzyme .
nomenclature
Systematically correct names of transferases are formed according to the following pattern: "Donor: acceptor group transferase". But other names are more common. The common names of transferases are formed as follows: "acceptor group transferase" or "donor group transferase". Example: A DNA methyl transferase is a transferase that catalyzes the transfer of a methyl group to a DNA acceptor.
EC classification
Transferases are categorized in the EC number classification system under EC 2.-.-.- . Transferases can be more specifically classified under ten subclasses:
- EC 2.1.-.- includes enzymes that transfer one- carbon groups
- EC 2.2.-.- includes enzymes that transfer aldehyde or keto groups
- EC 2.3.-.- includes acyltransferases
- EC 2.4.-.- includes glycosyl transferases
- EC 2.5.-.- includes enzymes that transfer alkyl or aryl groups
- EC 2.6.-.- includes enzymes that transfer nitro groups
- EC 2.7.-.- includes enzymes that transfer phosphorus-containing groups ( kinases )
- EC 2.8.-.- includes enzymes that transfer groups containing sulfur
- EC 2.9.-.- includes enzymes that transfer selenium-containing groups
- EC 2.10.-.- includes enzymes that transfer metal-containing groups ( Mo or W )
Examples
- Aspartate carbamoyl transferase ( EC 2.1.3.2 )
- Transaldolase ( EC 2.2.1.2 )
- Transglutaminase ( EC 2.3.2.13 )
- Aspartate aminotransferase ( EC 2.6.1.1 )
- Hexokinase ( EC 2.7.1.1 )
- Glycogen phosphorylase ( EC 2.7.1.37 )
- Pyruvate kinase ( EC 2.7.1.40 )
- DNA-dependent RNA polymerase ( EC 2.7.7.6 )
- RNA-dependent RNA polymerase ( EC 2.7.7.48 )
- Alcohol sulfotransferase ( EC 2.8.2.2 )
- Molybdopterin Molybdotransferase ( EC 2.10.1.1 )
Other classes of enzymes
- Oxidoreductases ( EC 1.-.-.- )
- Hydrolases ( EC 3.-.-.- )
- Lyases ( EC 4.-.-.- )
- Isomerases ( EC 5.-.-.- )
- Ligases ( EC 6.-.-.- )
Web links
- EC 2 Introduction to the Institute of Chemistry at Queen Mary University
- Enzyme nomenclature database (Engl.)