MHC restriction

The MHC restriction describes that antigens can only be recognized by T lymphocytes if they have been previously processed and presented on the cell surface on specific endogenous receptors , the class I and class II protein complexes encoded by the main histocompatibility complex (MHC) become.

The MHC restriction is a term from immunology that was introduced in 1974 in two pioneering papers by Rolf Zinkernagel and Peter Doherty . For their services in medical research, both received the Nobel Prize in Medicine in 1996 .

Individual evidence

↑ Zinkernagel, RM & Doherty, PC (1974): Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngenic and semiallogeneic system. In: Nature. Vol. 248, pp. 701-702. PMID 4133807
↑ Zinkernagel, RM & Doherty, PC (1974): Immunological surveillance against altered self components by sensitized T lymphocytes in lymphocytic choriomeningitis. In: Nature. Vol. 251, pp. 547-548. PMID 4547543

[1] Zinkernagel, RM & Doherty, PC (1974): Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngenic and semiallogeneic system. In: Nature. Vol. 248, pp. 701-702. PMID 4133807

[2] Zinkernagel, RM & Doherty, PC (1974): Immunological surveillance against altered self components by sensitized T lymphocytes in lymphocytic choriomeningitis. In: Nature. Vol. 251, pp. 547-548. PMID 4547543