Macrophagic myofasciitis

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The Macrophagic Myofasciitis ( MMF ; Greek myos , muscle '; fascia of Latin fasces , bundles'; itis , inflammation ') is a localized inflammation of the muscle connective tissue, which followed in 1993 for the first time almost exclusively in France was observed. It occurs near the puncture sites of previous vaccinations .

Opponents of the vaccination argue that there is a connection with aluminum compounds, especially aluminum hydroxide , which is contained in many dead vaccines as an enhancer of the immune system: Macrophages would migrate to the affected muscles and lock the particles there. However, the clinical relevance of the detected particles for the clinical picture of macrophagic myofaciitis is not tenable. Against such an assumption, the fact that the clinical picture of MMF was only observed from around 1998, but aluminum compounds as potentiators in vaccine sera had been in use for decades. Finally, MMF has practically not been seen outside of France, although aluminum-containing vaccines are used worldwide.

In  2003, the Global Advisory Committee for Vaccine Safety of the World Health Organization (WHO) discussed the results of a case-control study from France that investigated the possible association between local lesions after vaccination and systemic reactions. The committee concluded that persistence of aluminum-containing macrophages at the injection site is not associated with specific clinical symptoms or diseases. In a further Opinion in 2008, the Panel also found that more recent data from animal studies support the assumption that a marker for inflammatory reactions is a consequence of the persistence of aluminum at the injection site without causing further systemic symptoms. A clear causal relationship between vaccines containing aluminum hydroxide and MMF could not be proven.

literature

  • E. Rivas et al .: Macrophagic myofasciitis in childhood: a controversial entity . In: Pediatr Neurol. 2005, 33 (5), pp. 350-356, PMID 16243223 .
  • CA Siegrist: Vaccine adjuvants and macrophagic myofasciitis . In: Bull Acad Natl Med. 2003, 187 (8), pp. 1511-1518, PMID 15146582 .
  • RK Gherardi et al .: Macrophagic myofasziitis lesions assess longterm persistance of vaccine-derived aluminum hydroxide in muscle . In: Brain , 2001, 124, pp. 1821-1831, PMID 11522584 .

Web links

Individual evidence

  1. ↑ WHO | Macrophagic myofasciitis and aluminum-containing vaccines. Retrieved May 25, 2019 .
  2. ↑ a b J. -P. Goullé and L. Grangeot-Keros: Aluminum and vaccines: Current state of knowledge . In: Médecine et Maladies Infectieuses . October 11, 2019, doi : 10.1016 / j.medmal.2019.09.012 .
  3. ^ Stanley A. Plotkin et al .: Plotkin's Vaccines . 7th edition. Elsevier, 2017, ISBN 978-0-323-35761-6 , pp. 66 ( elsevier.com ).