Milan criteria

The Milan criteria or Milan criteria are used in patients with hepatocellular carcinoma (HCC) who also have liver cirrhosis . They are used to estimate the chances of success of the liver transplant and are used for listing for liver transplantation . According to scientific studies, patients who are transplanted within the Milan criteria should have a better long-term survival (75% after four years). The definition of the Milan criteria is as follows:

a lesion smaller than 5 cm
up to three lesions, each smaller or no larger than 3 cm
no extrahepatic manifestation
no vascular invasion (e.g. tumor thrombosis of the portal vein or liver veins )

Individual evidence

^ ^A ^b V. Mazzaferro, E. Regalia, R. Doci, S. Andreola, A. Pulvirenti, F. Bozzetti, F. Montalto, M. Ammatuna, A. Morabito, L. Gennari: Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. In: The New England Journal of Medicine . Volume 334, Number 11, March 1996, pp. 693-699, ISSN 0028-4793 . doi : 10.1056 / NEJM199603143341104 . PMID 8594428 .
↑ Guidelines for waiting lists and organ placement for liver transplantation (RiliOrgaLeber) (PDF, 213 kB)
^ V. Mazzaferro, JM Llovet, R. Miceli, S. Bhoori, M. Schiavo, L. Mariani, T. Camerini, S. Roayaie, ME Schwartz, GL Grazi, R. Adam, P. Neuhaus, M. Salizzoni, J. Bruix, A. Forner, L. De Carlis, U. Cillo, AK Burroughs, R. Troisi, M. Rossi, GE Gerunda, J. Lerut, J. Belghiti, I. Boin, J. Gugenheim, F. Rochling , B. Van Hoek, P. Majno: Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis. In: Lancet Oncology . Volume 10, Number 1, January 2009, pp. 35-43, ISSN 1474-5488 . doi : 10.1016 / S1470-2045 (08) 70284-5 . PMID 19058754 .
↑ V. Mazzaferro, p Bhoori, C. Sposito, M. Bongini, M. Langer, R. Miceli, L. Mariani: Milan criteria in liver transplantation for hepatocellular carcinoma: an evidence-based analysis of 15 years of experience. In: Liver Transplantation . Volume 17 Suppl 2, October 2011, pp. S44-S57, ISSN 1527-6473 . doi : 10.1002 / according to 22365 . PMID 21695773 . (Review).

[Mazzaferro-1] A ^b V. Mazzaferro, E. Regalia, R. Doci, S. Andreola, A. Pulvirenti, F. Bozzetti, F. Montalto, M. Ammatuna, A. Morabito, L. Gennari: Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. In: The New England Journal of Medicine . Volume 334, Number 11, March 1996, pp. 693-699, ISSN 0028-4793 . doi : 10.1056 / NEJM199603143341104 . PMID 8594428 .

[2] Guidelines for waiting lists and organ placement for liver transplantation (RiliOrgaLeber) (PDF, 213 kB)

[3] V. Mazzaferro, JM Llovet, R. Miceli, S. Bhoori, M. Schiavo, L. Mariani, T. Camerini, S. Roayaie, ME Schwartz, GL Grazi, R. Adam, P. Neuhaus, M. Salizzoni, J. Bruix, A. Forner, L. De Carlis, U. Cillo, AK Burroughs, R. Troisi, M. Rossi, GE Gerunda, J. Lerut, J. Belghiti, I. Boin, J. Gugenheim, F. Rochling , B. Van Hoek, P. Majno: Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis. In: Lancet Oncology . Volume 10, Number 1, January 2009, pp. 35-43, ISSN 1474-5488 . doi : 10.1016 / S1470-2045 (08) 70284-5 . PMID 19058754 .

[4] V. Mazzaferro, p Bhoori, C. Sposito, M. Bongini, M. Langer, R. Miceli, L. Mariani: Milan criteria in liver transplantation for hepatocellular carcinoma: an evidence-based analysis of 15 years of experience. In: Liver Transplantation . Volume 17 Suppl 2, October 2011, pp. S44-S57, ISSN 1527-6473 . doi : 10.1002 / according to 22365 . PMID 21695773 . (Review).