Pannexins

Pannexins are members of a family of proteins in animals that can be found in various parts of the human body and are related to the connexin family. These are structural proteins that are made up of a few hundred amino acid building blocks. Pannexins form ATP channels in erythrocytes , are involved in the release of interleukin-1 and form gap junctions in the brain . A role in carcinogenesis is discussed. Three pannexins are known in humans:

protein	Gene (HGNC)	UniProt	Length (AA)
Pannexin-1	PANX1	Q96RD7	426
Pannexin-2	PANX2	Q96RD6	677
Pannexin-3	PANX3	Q96QZ0	392

literature

MT Barbe, H. Monyer, R. Bruzzone: Cell-cell communication beyond connexins: the pannexin channels. In: Physiology Volume 21, April 2006, pp. 103-114, doi : 10.1152 / physiol.00048.2005 . PMID 16565476 .
C. D'hondt, R. Ponsaerts, et al. a .: Pannexins, distant relatives of the connexin family with specific cellular functions? In: BioEssays: news and reviews in molecular, cellular and developmental biology. Volume 31, number 9, September 2009, pp. 953-974, doi : 10.1002 / bies.200800236 . PMID 19644918 .
MR Yen, MH Saier: Gap junctional proteins of animals: the innexin / pannexin superfamily. In: Progress in biophysics and molecular biology. Volume 94, number 1-2, 2007 May-Jun, pp. 5-14, doi : 10.1016 / j.pbiomolbio.2007.03.006 . PMID 17507077 . PMC 2592087 (free full text).
RJ Thompson, BA Macvicar: Connexin and pannexin hemichannels of neurons and astrocytes. In: Channels (Austin, Tex.). Volume 2, Number 2, 2008 Mar-Apr, pp. 81-86, PMID 18849665 .
KA Schalper, JA Orellana u. a .: Dysfunctions of the diffusional membrane pathways mediated by hemichannels in inherited and acquired human diseases. In: Current Vascular Pharmacology . Volume 7, Number 4, October 2009, pp. 486-505, PMID 19485891 .
C. D'hondt, R. Ponsaerts, et al. a .: Pannexin channels in ATP release and beyond: an unexpected rendezvous at the endoplasmic reticulum. In: Cellular signaling. Volume 23, number 2, February 2011, pp. 305-316, doi : 10.1016 / j.cellsig.2010.07.018 . PMID 20688156 .