Parallel synthesis

The parallel synthesis is a method for the simultaneous and automated synthesis and purification of a large number of structurally similar compounds for pharmaceutical-chemical research. As a result, many times more test substances can be synthesized in a short period of time than in conventional synthesis.

The parallel synthesis is particularly important in studies of the structure-activity relationship (QSAR). In this way, the optimization of new active ingredients is shortened. In the parallel synthesis, however, no individual reactions are followed. Many reaction steps of the individual synthesis can only be applied to the parallel synthesis after the reaction conditions have been optimized. The hit rate of target molecules is lower due to the parallel synthesis compared to the classic single synthesis.

The parallel synthesis can be carried out either in solution or as a solid phase reaction.

literature

• David G. Cork, Tohru Sugawara: Laboratory Automation in the Chemical Indus . CRC Press, 2002, ISBN 978-0-203-90894-5 , pp. 159 ( limited preview in Google Book search).
• D. Obrecht, JM Villalgordo: Solid-Supported Combinatorial and Parallel Synthesis of Small-Molecular-Weight Compound Libraries . Elsevier, 1998, ISBN 978-0-08-051736-0 , pp. 338 .

Web links

• Lecture script (PDF; 487 kB)

See also

• Combinatorial Chemistry

Individual evidence

1. ↑ Gerhard Klebe: drug design, design and effect of drugs . Springer-Verlag, 2009, ISBN 978-3-8274-2213-2 , pp. 618 ( limited preview in Google Book search).
2. ↑ Dagmar Fischer, Jörg Breitenbach (Ed.): The pharmaceutical industry . 4th edition. Springer-Verlag, Berlin / Heidelberg 2013, ISBN 978-3-8274-2923-0 , pp. 73 , doi : 10.1007 / 978-3-8274-2924-7 .