Receptor Activity Modifying Proteins

from Wikipedia, the free encyclopedia

Receptor activity-modifying protein ( Receptor activity-modifying proteins , short RAMPS ) are proteins that by dimerization with a G protein-coupled receptor control its conformation and thus its cellular transport. Five different receptor activity-modifying proteins are currently known: RAMP1, RAMP2, RAMP3, RAMP4 and RAMP5.

Through their connection, however, not only can the receptor be transported to the cell membrane, but the function of the receptor itself can also be modulated. One example is the calcitonin receptor-like receptor ( calcitonin receptor-like receptor ), which in the presence of RAMP1 as a receptor for the calcitonin gene-related peptide ( calcrl than) and in the presence of RAMP2 Acting receptor for adrenomedullin ( adrenomedullin receptor ).

literature

  • PM Sexton, M. Morfis, N. Tilakaratne, DL Hay, M. Udawela, G. Christopoulos, A. Christopoulos: Complexing receptor pharmacology: modulation of family BG protein-coupled receptor function by RAMPs. In: Ann NY Acad Sci. 1070, 2006, pp. 90-104. doi: 10.1196 / annals.1317.076 . PMID 16888151 .
  • A. Young: Amylin: Physiology and Pharmacology; Chapter 3: Receptor pharmacology. In: Advances in Pharmacology. 52, 2005, pp. 47-65. doi: 10.1016 / S1054-3589 (05) 52003-9 , ISBN 0-12-032954-9 . PMID 16492540 .
  • LM McLatchie, NJ Fraser, MJ Main, A. Wise, J. Brown, N. Thompson, R. Solari, MG Lee, SM Foord: RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. In: Nature. 393 (6683), May 1998, pp. 333-339. doi: 10.1038 / 30666 . PMID 9620797 .
  • SM Foord, FH Marshall: RAMPs: accessory proteins for seven transmembrane domain receptors. In: Trends Pharmacol. Sci. 20 (5), May 1999, pp. 184-187. doi: 10.1016 / S0165-6147 (99) 01347-4 . PMID 10354609 .
  • S. Kamitani, M. Asakawa, Y. Shimekake, K. Kuwasako, K. Nakahara, T. Sakata: The RAMP2 / CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells. In: FEBS Lett. 448 (1), April 1999, pp. 111-114. doi: 10.1016 / S0014-5793 (99) 00358-0 . PMID 10217420 .