Spaetzle-processing enzymes
| Spaetzle-processing enzymes | ||
|---|---|---|
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| Precursor | 400 amino acids , 43,947 Da | |
| Identifier | ||
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| Enzyme classification | ||
| EC, category | 3.4.21.- | |
Spaetzle-processing Enzyme (SPE) is a protease from the fruit fly Drosophila melanogaster .
properties
Spaetzle-processing Enzyme is an endopeptidase and a serine protease . Spaetzle-processing Enzyme splits Spaetzle into its active form, which activates the Toll receptor . Spaetzle-processing enzyme is itself formed as a preprotein and split into the active form by proteases. After the signal peptide (amino acids 1–27) has been cleaved, another cut is made after amino acid 134. However, the last two fragments remain connected to one another as SPE light and heavy chains.
In response to Gram-positive bacteria, PGRP-SA and GNBP1 are activated and then the Protease Grass before spaetzle-processing enzymes are activated. In response to fungi , the protease Psh is activated before spaetzle-processing enzymes are activated. Spaetzle-processing Enzyme is glycosylated , binds divalent calcium ions and has disulfide bridges .