Systemic Inflammatory Response Syndrome

Classification according to ICD-10
R65.0	Systemic inflammatory response syndrome [SIRS] of infectious origin without organ complications
R65.1	Systemic inflammatory response syndrome [SIRS] of infectious origin with organ complications
R65.2	Systemic inflammatory response syndrome [SIRS] of non-infectious origin without organ complications
R65.3	Systemic inflammatory response syndrome [SIRS] of non-infectious origin with organ complications
R65.9	Systemic Inflammatory Response Syndrome [SIRS], unspecified
ICD-10 online (WHO version 2019)

Systemic inflammatory response syndrome ( SIRS - English systemic inflammatory response syndrome ) is the medical term for a systemic inflammatory reaction of the organism , in which it takes place throughout the body, regardless of where it was triggered, while a local inflammatory reaction to a specific one Body region remains limited.

Diagnosis

At least two of the following criteria must be met in order to be able to diagnose SIRS:

1. Body temperature ≥ 38  ° C (increased body temperature above subfebrile temperatures) or ≤ 36 ° C
2. Heart rate ≥ 90 / min ( tachycardia )
3. Tachypnea : respiratory rate ≥ 20 / min or hyperventilation with p CO ₂ ≤ 32 mmHg
4. Leukocytosis (≥ 12000 / μl) or leukopenia (≤ 4000 / μl) or shift to the left (i.e.> 10% immature granulocytes in the differential blood count ).

The combination of fever + leukocytosis is the more common one and suggests an adequate to excessive reaction of the immune system, while the combination of body temperature <36 ° C + leukopenia , also known as cold SIRS , is less common and usually occurs in the case of immune deficiency .

If the SIRS is caused by an infection , it is called sepsis .

causes

Causes of SIRS can be: immunological , chemical reasons (e.g. acute pancreatitis ), shock , burns , major operations (especially operations with extracorporeal circulation such as large heart operations or large wound areas), severe trauma or various serious illnesses (e.g. necrotizing pancreatitis ).

Web links

• Definition of the SIRS (PDF file; 26 kB)
• DIMDI FAQ entry on SIRS
• S-2 Guideline for the prevention, diagnosis, therapy and aftercare of sepsis, German Sepsis Society

Individual evidence

1. ^ Gerd Herold and colleagues: Internal medicine . Ed .: Dr. med. Gerd Herold. 2017th edition. S. 323 .

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !