Thyrotropin receptor

The thyrotropin receptor , also known as the TSH receptor , is a G-protein coupled receptor for thyrotropin on the thyrocytes , whose activity it stimulates.

There are two signal pathways: 1) The release of thyroid hormones and the growth of the thyroid gland are stimulated via the G _s protein and the cAMP signal path.

2) Hormone production is increased via the G _q protein via the phosphoinositol pathway. This is achieved through the induction of dual oxidase (DUOX) and thyroglobulin biosynthesis .

Even without binding to the thyrotropin ligand, the thyrotropin receptor has a basic activity . A disruption of sulfation by protein tyrosine sulfotransferase 2 can lead to a lack of growth and impaired hormone synthesis in the thyroid .

Individual evidence

↑ ^a ^b ^c Löffler / Petridas: Biochemistry and Pathobiochemistry . 9th edition. Springer-Verlag, Berlin 2014, ISBN 978-3-642-17972-3 , pp. 515 .

[Biochemie_und_Pathobiochemie_515-1] Löffler / Petridas: Biochemistry and Pathobiochemistry . 9th edition. Springer-Verlag, Berlin 2014, ISBN 978-3-642-17972-3 , pp. 515 .