Tunneling nanotubes

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Tunneling nanotubes (TNTs) are thin membrane channels with a diameter in the nanometer range , which connect animal cells into complex and apparently ordered networks and thus enable the intercellular transfer of diverse biomolecules. They may be involved in a variety of physiological and pathological mechanisms, e.g. B. in the transfer of major histocompatibility complexes (MHCs) at immunological synapses, the intercellular distribution of viral proteins or the exchange of tumor resistance in cancer .

Original work

  • Amin Rustom, Rainer Saffrich, Ivanka Markovic, Paul Walther, Hans-Hermann Gerdes: Nanotubular Highways for Intercellular Organelle Transport . In: Science . tape 303 , no. 5660 , February 2004, p. 1007-1010 , doi : 10.1126 / science.1093133 , PMID 14963329 (free full text).
  • E. Hodneland, A. Lundervold, S. Gurke, X.-C. Tai, A. Rustom, H.-H. Gerdes: Automated detection of tunneling nanotubes in 3D images . In: Cytometry Part A . 69A, no. 9 , September 2010, ISSN  1552-4930 , p. 961-972 , doi : 10.1002 / cyto.a.20302 , PMID 16969816 (free full text).
  • Anne Chauveau, Anne Aucher, Philipp Eissmann, Eric Vivier, Daniel M. Davis: Membrane nanotubes facilitate long-distance interactions between natural killer cells and target cells . In: PNAS . tape 107 , no. 12 , March 23, 2010, p. 5545-5550 , doi : 10.1073 / pnas.0910074107 , PMID 20212116 , PMC 2851811 (free full text).

Web links

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