Very low density lipoprotein
Very low density lipoprotein (VLDL) is a component of the blood plasma and is used to transport triglycerides , cholesterol and phospholipids from the liver to the tissues . On its way, it converts to LDL through the gradual release of the triglycerides from VLDL .
VLDLs are very low density lipoproteins that are synthesized in the liver. Their lipid content is 85–90%, their protein content accordingly 10–15%. The apolipoproteins ApoB 100 and ApoE stabilize the VLDL. After entering the bloodstream , there are interactions with HDL , which release the apolipoproteins ApoE and ApoC-II to the VLDLs. The latter mediates the cleavage of free fatty acids from triacylglycerides by means of lipoprotein lipase, which is effective in the capillary endothelium. After the release of triacylglycerides, lipoproteins, intermediate density lipoprotein (IDL), are formed from the released VLDLs , the density of which is higher due to the lower fat content.
VLDLR is the abbreviation for the "very low density lipoprotein receptor ", a receptor to which the VLDL docks.