Vav proteins
Vav proteins are GTP exchange factors for Rho GTPases . As a result, they act in the signal line of cells. There are three different Vav proteins in mammalian cells. While Vav-1 on hematopoietic cells is restricted, Vav-2 and Vav-3 are in different cell types expressed . All three contain a DH (Dbl-homology) domain, which catalyzes the GTP exchange in small Rho GTPases, a PH (pleckstrin-homology) domain and an SH2 domain which is bordered by two SH3 domains.
Human Vav Proteins
| Gene name | UniProt | amino acids | OMIM | comment |
| VAV1 | P15498 | 845 | 164875 | Zinc fingers , proto-oncogene |
| VAV2 | P52735 | 847 | 600428 | 3 isoforms , zinc fingers, angiogenesis |
| VAV3 | Q9UKW4 | 878 | 605541 | 2 isoforms, zinc fingers, angiogenesis |
Individual evidence
- ↑ XR Bustelo, SD Rubin, KL Suen, D. Carrasco, M. Barbacid : Developmental expression of the vav protooncogene. In: Cell Growth & Differentiation: the Molecular Biology Journal of the American Association for Cancer Research , 1993, 4 (4), pp. 297-308, PMID 8494792
- ↑ KE Schuebel et al .: Isolation and characterization of murine vav-2, a member of the vav family of proto-oncogenes. In: Oncogene 13, 1996, pp. 363-371
- ^ Nieves Movilla, Xosé R. Bustelo: Biological and Regulatory Properties of Vav-3, a New Member of the Vav Family of Oncoproteins . In: Molecular and Cellular Biology , November 1999, Vol. 19, No. 11, pp. 7870-7885
- ↑ Bustelo et al .: Regulatory and signaling properties of the Vav family . In: Mol. Cell Biol. 20, 2000, pp. 1461-1477