TBE virus

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TBE virus
Tick-Borne Encephalitis Virus.png

TBE viruses
Fig. A: pH = 8.0
Fig. B: pH = 10.0
Fig. C: pH = 5.4

Systematics
Classification : Viruses
Area : Riboviria
Empire : Orthornavirae
Phylum : Kitrinoviricota
Class : Flasuviricetes
Order : Amarillovirales
Family : Flaviviridae
Genre : Flavivirus
Type : TBE virus
Taxonomic characteristics
Genome : (+) ss RNA
Baltimore : Group 4
Scientific name
Tick-borne encephalitis virus
Short name
TBEV
Left
NCBI  Taxonomy: 11084
ICTV Taxon History: 201853114
ICTVdB Virus Code : 00.026.0.01.046.02

The TBE virus ( FSMEV , scientifically Tick-borne encephalitis virus , TBEV ) is a species of enveloped single-stranded RNA viruses of positive polarity and the causative agent of early summer meningoencephalitis (TBE or TBE). It is a human pathogenic virus from the Flaviviridae family , genus Flavivirus .

Subtypes

There are three subtypes.

  • Far Eastern Subtype : Far-Eastern tick-borne encephalitis virus (Far-Eastern TBEV) , formerly Russian Spring-Summer Encephalitis Virus (RSSEV) - occurs mainly in Russia , east of the Urals and parts of China, Japan and Korea . The carrier of this subtype is Ixodes persulcatus (taiga tick ), the mortality of this subtype is up to 20%.
  • Western European Subtype : Western tick-borne encephalitis virus (WTBEV) , formerly Central-European-Encephalitis-Virus (CEEV) - Occurrence in Central, Eastern and Northern Europe. The carrier is Ixodes ricinus (common wood tick ), lethality is up to 2%.
  • Siberian Subtype : Siberian tick-borne encephalitis virus (STBEV) , formerly West Siberian virus - Occurrence in (West) Siberia. The carrier is Ixodes persulcatus

The type line is the Sofjin strain .

features

The virus capsid consists of three structural proteins :

  • Envelope protein E.
  • Core protein C
  • Membrane protein

The glycoprotein E plays a central role in the biology of the infection and is responsible for binding and penetration into the target cell. It is one of the best characterized viral proteins .

Carrier

Ticks (Ixodida sp.) Are the main vectors and main reservoir of TBE. The infection occurs through tick bites or through raw milk from infected animals. The disease itself was first described in 1931 in forest workers from Neunkirchen , and the pathogen was isolated in 1949.

The endemic occurrence of TBE is always associated with large rivers. The reasons for this are still unclear.

Systematics

The species TBEV belongs within the genus Flavivirus to the so-called tick-borne encephalitis complex (TBE), to which, in addition to these pathogens of early summer meningoencephalitis, the Louping Ill virus (pathogen of Looping III, LI), the Kyasanur -Forest Disease Virus (causative agent of Kyasanur forest fever, KFD) with the subtype Al-Khurma virus , Powassan virus (causative agent of Powassan virus encephalitis, PE), Omsk hemorrhagic fever virus ( Causative agent of Omsk fever), the Langat virus , as well as the pathogens of Negeshivirus encephalitis. The individual species are each limited to certain regions.

Reporting requirement

In Germany, the direct or indirect detection of is TBE virus name notifiable according to § 7 of the infection protection law (IfSG), unless the evidence of acute infection points. The obligation to notify primarily concerns the management of laboratories ( § 8 IfSG).

In Switzerland, the positive and negative laboratory analytical findings on a tick encephalitis virus must be reported to laboratories in accordance with the Epidemics Act (EpG) in conjunction with the Epidemics Ordinance and Annex 3 of the EDI Ordinance on the reporting of observations of communicable diseases in humans .

literature

Web links

Wiktionary: TBE virus  - explanations of meanings, word origins, synonyms, translations

Individual evidence

  1. ↑ ICTV Master Species List 2018b.v2 . MSL # 34, March 2019
  2. ↑ a b c d ICTV: ICTV Taxonomy history: Yellow fever virus , EC 51, Berlin, Germany, July 2019; Email ratification March 2020 (MSL # 35)
  3. ^ FX Heinz: Tick-borne encephalitis virus: advances in molecular biology and vaccination strategy in the next century . In: Zentralbl. Bacteriol. . Volume 289, No. 5-7, 1999, ISSN 0934-8840 , pp. 506-510. PMID 10652717 .  
  4. ↑ Jesse L. Goodman, David T. Dennis, Daniel E. Sonenshine, et al. : Tick-Borne Encephalitis . In: Tick-Borne Diseases of Humans . ASM Press, Washington, DC 2005, ISBN 978-1-55581-238-6 , p. 151.
  5. ↑ Kovalev SY, Mukhacheva TA, Kokorev VS, Belyaeva IV: Tick-borne encephalitis virus: reference strain Sofjin and problem of its authenticity . In: Virus Genes . 44, No. 2, April 2012, pp. 217-24. doi : 10.1007 / s11262-011-0690-9 . PMID 22095094 .
  6. ^ NCBI: tick-borne encephalitis virus group