Cloprostenol: Difference between revisions
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Entranced98 (talk | contribs) Importing Wikidata short description: "Chemical compound" |
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{{Short description|Chemical compound}} |
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{{unreferenced|date=December 2016}} |
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{{Drugbox |
{{Drugbox |
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| IUPAC_name = (5Z)-7-{(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-Chlorophenoxy)-3-hydroxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl}-5-heptenoic acid |
| IUPAC_name = (5Z)-7-{(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-Chlorophenoxy)-3-hydroxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl}-5-heptenoic acid |
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<!-- Identifiers --> |
<!-- Identifiers --> |
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| CAS_number = 40665-92-7 |
| CAS_number = 40665-92-7 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII = 4208238832 |
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| ATCvet = yes |
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| ATC_prefix = G02 |
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| ATC_suffix = AD90 |
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| PubChem = 5311053 |
| PubChem = 5311053 |
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| ChemSpiderID = 4470590 |
| ChemSpiderID = 4470590 |
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'''Cloprostenol''' is a synthetic analogue of [[Prostaglandin F2alpha|prostaglandin F<sub>2α</sub>]] (PGF<sub>2α</sub>).<ref name="Cooper 1981"/> It is a potent luteolytic agent; this means that, within hours of administration, it causes the [[corpus luteum]] to stop production of [[progesterone]], and to reduce in size over several days.<ref name="Cooper 1981">{{cite journal | vauthors = Cooper M | title = Prostaglandins in veterinary practice | journal = In Practice | volume = 3 | issue = 1 | pages = 30, 32-4 | date = January 1981 | pmid = 7346485 | doi = 10.1136/inpract.3.1.30 | s2cid = 6197103 }}</ref> This effect is used in animals to induce [[estrus]] and to cause abortion.<ref name="Plumb 2015">{{cite book| vauthors = Plumb DC |title=Plumb's Veterinary Drug Handbook|date=2015|publisher=Wiley|isbn=9781118911938|edition=8th|chapter=Cloprostenol Sodium}}</ref> |
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'''Cloprostenol''' is a synthetic prostaglandin analogue structurally related to prostaglandin F2-α (PGF2 α). It causes functional and morphological regression of the corpus luteum (luteolysis) in cattle. |
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== References == |
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{{Reflist}} |
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[[Category:Cyclopentanes]] |
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{{Veterinary-med-stub}} |
{{Veterinary-med-stub}} |
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Latest revision as of 12:24, 29 January 2023
Clinical data | |
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Trade names | Cyclomate, Estrumate |
Routes of administration | Intramuscular |
ATCvet code | |
Pharmacokinetic data | |
Excretion | 67% renal, 25% fecal |
Identifiers | |
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CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.050.009 |
Chemical and physical data | |
Formula | C22H29ClO6 |
Molar mass | 424.915 |
3D model (JSmol) | |
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Cloprostenol is a synthetic analogue of prostaglandin F2α (PGF2α).[1] It is a potent luteolytic agent; this means that, within hours of administration, it causes the corpus luteum to stop production of progesterone, and to reduce in size over several days.[1] This effect is used in animals to induce estrus and to cause abortion.[2]