User:Pdeitiker/HLA-B template: Difference between revisions
Content deleted Content added
mNo edit summary |
mNo edit summary |
||
| Line 25: | Line 25: | ||
{{Further|[[HLA-A#Historical Guide to Understanding Nomenclature|HLA-serotype tutorial]]}} |
{{Further|[[HLA-A#Historical Guide to Understanding Nomenclature|HLA-serotype tutorial]]}} |
||
B52 is a [[wikt:split antigen|split antigen]] of the [[wikt:broad antigen|broad antigen]] [[HLA-B5|B5]], and is a sister type of [[HLA- |
B52 is a [[wikt:split antigen|split antigen]] of the [[wikt:broad antigen|broad antigen]] [[HLA-B5|B5]], and is a sister type of [[HLA-B51|B51]]. B*5201 likely formed as a result of a [[gene conversion]] event between another HLA-B allele and HLA-B*5101.<ref name="pmid12622774">{{cite journal |author=Cox ST, McWhinnie AJ, Robinson J, ''et al'' |title=Cloning and sequencing full-length HLA-B and -C genes |journal=Tissue Antigens |volume=61 |issue=1 |pages=20–48 |year=2003 |month=January |pmid=12622774 |doi= |url=http://www.ebi.ac.uk/~sp/intern/projects/pdf_archive/pdfpumped/4/12622774.pdf}}</ref> |
||
There are a number of alleles within the B*52 allele group.<ref name="pmid2909619">{{cite journal |author=Hayashi H, Ennis PD, Ariga H, ''et al'' |title=HLA-B51 and HLA-Bw52 differ by only two amino acids which are in the helical region of the alpha 1 domain |journal=J. Immunol. |volume=142 |issue=1 |pages=306–11 |year=1989 |month=January |pmid=2909619 |doi= |url=http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=2909619}}</ref> |
There are a number of alleles within the B*52 allele group.<ref name="pmid2909619">{{cite journal |author=Hayashi H, Ennis PD, Ariga H, ''et al'' |title=HLA-B51 and HLA-Bw52 differ by only two amino acids which are in the helical region of the alpha 1 domain |journal=J. Immunol. |volume=142 |issue=1 |pages=306–11 |year=1989 |month=January |pmid=2909619 |doi= |url=http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=2909619}}</ref> |
||
Revision as of 01:05, 3 August 2008
| ||
| B*5101-β2MG with bound peptide 1e27 | ||
major histocompatibility complex (human), class I, B52
| ||
| Alleles | B*5201, 5202, 5203, . . . | |
| Structure (See HLA-B) | Available 3D structures | |
HLA-B52 (B52) is an HLA-B serotype. The serotype identifies the more common HLA-B*52 gene products.[1]
B52 is a split antigen of the broad antigen B5, and is a sister type of B51. B*5201 likely formed as a result of a gene conversion event between another HLA-B allele and HLA-B*5101.[2] There are a number of alleles within the B*52 allele group.[3]
Serotype
| B*52 | B52 | B5 | B52 | B53 | Sample |
| allele | % | % | % | % | size (N) |
| Template:HBA | 82 | 2 | 7 | 1 | 2823 |
| Alleles link-out to IMGT/HLA Databease at EBI | |||||
Alleles
There are 18 alleles, with 14 amino acid sequence variants in B52. Of these only 9 are frequent enough to have been reliably serotyped. B*5201 is the most common, but others have a large regional abundance.
References
- ^ Marsh SG, Albert ED, Bodmer WF; et al. (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens. 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - ^ Cox ST, McWhinnie AJ, Robinson J; et al. (2003). "Cloning and sequencing full-length HLA-B and -C genes" (PDF). Tissue Antigens. 61 (1): 20–48. PMID 12622774.
{{cite journal}}: Explicit use of et al. in:|author=(help); Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Hayashi H, Ennis PD, Ariga H; et al. (1989). "HLA-B51 and HLA-Bw52 differ by only two amino acids which are in the helical region of the alpha 1 domain". J. Immunol. 142 (1): 306–11. PMID 2909619.
{{cite journal}}: Explicit use of et al. in:|author=(help); Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ derived from IMGT/HLA