UCP3: Difference between revisions
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==Interactions== |
==Interactions== |
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UCP3 has been shown to [[Protein-protein interaction|interact]] with [[YWHAQ]].<ref name=pmid10785390>{{cite journal |last=Pierrat |first=B |authorlink= |coauthors=Ito M, Hinz W, Simonen M, Erdmann D, Chiesi M, Heim J |year=2000|month=May |
UCP3 has been shown to [[Protein-protein interaction|interact]] with [[YWHAQ]].<ref name=pmid10785390>{{cite journal |last=Pierrat |first=B |authorlink= |coauthors=Ito M, Hinz W, Simonen M, Erdmann D, Chiesi M, Heim J |year=2000|month=May |title=Uncoupling proteins 2 and 3 interact with members of the 14.3.3 family |journal=Eur. J. Biochem. |volume=267 |issue=9 |pages=2680–7 |publisher= |location = GERMANY| issn = 0014-2956| pmid = 10785390 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1046/j.1432-1327.2000.01285.x }}</ref> |
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==See also== |
==See also== |
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Revision as of 18:24, 9 January 2014
Template:PBB Mitochondrial uncoupling protein 3 is a protein that in humans is encoded by the UCP3 gene.[1][1][2][2]
Function
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known.[3]
Structure
UCPs contain the three homologous protein domains of MACPs.[3]
Gene regulation
This gene has tissue-specific transcription initiation with other transcription initiation sites upstream of SM-1 (major skeletal muscle site). Chromosomal order is 5'-UCP3-UCP2-3'. Two splice variants have been found for this gene.[3]
Disease association
Mutations in the UCP3 gene are associated with obesity.[4][5]
Interactions
UCP3 has been shown to interact with YWHAQ.[6]
See also
References
- ^ a b Boss O, Giacobino JP, Muzzin P (1998). "Genomic structure of uncoupling protein-3 (UCP3) and its assignment to chromosome 11q13". Genomics. 47 (3): 425–6. doi:10.1006/geno.1997.5135. PMID 9480760.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) Cite error: The named reference "pmid9480760" was defined multiple times with different content (see the help page). - ^ a b Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB (1997). "UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue". Biochem Biophys Res Commun. 235 (1): 79–82. doi:10.1006/bbrc.1997.6740. PMID 9196039.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) Cite error: The named reference "pmid9196039" was defined multiple times with different content (see the help page). - ^ a b c "Entrez Gene: UCP3 uncoupling protein 3 (mitochondrial, proton carrier)".
- ^ Argyropoulos G, Brown AM, Willi SM, Zhu J, He Y, Reitman M, Gevao SM, Spruill I, Garvey WT (1998). "Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes". J. Clin. Invest. 102 (7): 1345–51. doi:10.1172/JCI4115. PMC 508981. PMID 9769326.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Dalgaard LT; Sørensen TI; Drivsholm T; et al. (2001). "A prevalent polymorphism in the promoter of the UCP3 gene and its relationship to body mass index and long term body weight change in the Danish population". J. Clin. Endocrinol. Metab. 86 (3): 1398–402. doi:10.1210/jc.86.3.1398. PMID 11238538.
{{cite journal}}: Unknown parameter|author-separator=ignored (help); Unknown parameter|month=ignored (help) - ^ Pierrat, B (2000). "Uncoupling proteins 2 and 3 interact with members of the 14.3.3 family". Eur. J. Biochem. 267 (9). GERMANY: 2680–7. doi:10.1046/j.1432-1327.2000.01285.x. ISSN 0014-2956. PMID 10785390.
{{cite journal}}: Cite has empty unknown parameters:|laydate=,|laysummary=, and|laysource=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help)
Further reading
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