Uncoupling protein

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Mitochondrial uncoupling protein 2

An uncoupling protein is a mitochondrial membrane protein that lets protons through the mitochondrial membrane without chemiosmotic coupling and thus decouples the respiratory chain .

properties

There are five types in mammals:

Uncoupling protein are used for thermogenesis , as the protons on fatty acids bound from the interior of the mitochondrion to the membrane-bound ATPase past the cytoplasm be funneled to the heat of neutralization to produce. Chemical decouplers of the respiratory chain are z. B. 2,4-dinitrophenol , carbonyl cyanide m-chlorophenyl hydrazone (CCCP), malachite green , salicylic acid and sometimes acetic acid . UCP are induced by thyroid hormones , adrenaline , noradrenaline, and leptin .

Web links

Individual evidence

  1. ↑ Nedergaard J, Ricquier D, Kozak LP: Uncoupling proteins: current status and therapeutic prospects . In: EMBO Rep. . 6, No. 10, 2005, pp. 917-21. doi : 10.1038 / sj.embor.7400532 . PMID 16179945 . PMC 1369193 (free full text).
  2. ^ RK Porter: Uncoupling protein 1: a short circuit in the chemiosmotic process. In: Journal of bioenergetics and biomembranes. Volume 40, Number 5, October 2008, pp. 457-461, doi : 10.1007 / s10863-008-9172-8 . PMID 18958609 .
  3. ↑ S. Diano, TL Horvath: Mitochondrial uncoupling protein 2 (UCP2) in glucose and lipid metabolism. In: Trends in Molecular Medicine . Volume 18, number 1, January 2012, pp. 52-58, doi : 10.1016 / j.molmed.2011.08.003 . PMID 21917523 .
  4. ↑ M. Nabben, J. Hoeks: Mitochondrial uncoupling protein 3 and its role in cardiac and skeletal muscle metabolism. In: Physiology & behavior. Volume 94, number 2, May 2008, pp. 259-269, doi : 10.1016 / j.physbeh.2007.11.039 . PMID 18191161 .
  5. ↑ PW Ho, JW Ho, HM Tse, DH So, DC Yiu, HF Liu, KH Chan, MH Kung, DB Ramsden, SL Ho: Uncoupling protein-4 (UCP4) increases ATP supply by interacting with mitochondrial Complex II in neuroblastoma cells . In: PLOS ONE . Volume 7, number 2, 2012, p. E32810, doi : 10.1371 / journal.pone.0032810 . PMID 22427795 . PMC 3303587 (free full text).
  6. ↑ PW Ho, AC Chu, KH Kwok, MH Kung, DB Ramsden, SL Ho: Knockdown of uncoupling protein-5 in neuronal SH-SY5Y cells: Effects on MPP + -induced mitochondrial membrane depolarization, ATP deficiency, and oxidative cytotoxicity. In: Journal of neuroscience research. Volume 84, number 6, 2006, pp. 1358-1366, doi : 10.1002 / jnr.21034 . PMID 16941493 .
  7. ↑ P. Jezek, M. Jab? Rek, KD Garlid: Channel character of uncoupling protein-mediated transport. In: FEBS letters. Volume 584, number 10, 2010, pp. 2135-2141, doi : 10.1016 / j.febslet.2010.02.068 . PMID 20206627 . PMC 3617986 (free full text).
  8. ↑ Y. Jin, ML McEwen, SA Nottingham, WF Maragos, NB Dragicevic, PG Sullivan, JE Springer: The mitochondrial uncoupling agent 2,4-dinitrophenol improves mitochondrial function, attenuates oxidative damage, and increases white matter sparing in the contused spinal cord . In: Journal of neurotrauma. Volume 21, Number 10, October 2004, pp. 1396-1404, PMID 15672630 .
  9. ↑ K. Kaila, K. Mattsson, J. Voipio: Fall in intracellular pH and increase in resting tension induced by a mitochondrial uncoupling agent in crayfish muscle. In: The Journal of Physiology. Volume 408, January 1989, pp. 271-293, PMID 2778730 . PMC 1190403 (free full text).
  10. ↑ G. Werth, A. Boiteux: Toxicity of triphenylmethane dyes. Malachite green as an uncoupling agent of oxidative phosphorylation in vivo and in vitro. In: Archives for Toxicology. Volume 23, Number 2, 1968, pp. 82-103, PMID 4299566 .
  11. ↑ Gong DW, He Y, Karas M, Reitman M: Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, β3-adrenergic agonists, and leptin . In: J Biol Chem . 272, No. 39, 1997, pp. 24129-24132. doi : 10.1074 / jbc.272.39.24129 .