UCP3: Difference between revisions
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== Function == |
== Function == |
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[[Mitochondrion|Mitochondrial]] uncoupling proteins (UCP) are members of the larger family of [[mitochondrial carrier|mitochondrial anion carrier]] proteins (MACP). UCPs separate [[oxidative phosphorylation]] from [[ATP synthase|ATP synthesis]] with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H<sup>+</sup>/OH<sup> |
[[Mitochondrion|Mitochondrial]] uncoupling proteins (UCP) are members of the larger family of [[mitochondrial carrier|mitochondrial anion carrier]] proteins (MACP). UCPs separate [[oxidative phosphorylation]] from [[ATP synthase|ATP synthesis]] with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H<sup>+</sup>/OH<sup>−</sup> are not known.<ref name="entrez">{{cite web | title = Entrez Gene: UCP3 uncoupling protein 3 (mitochondrial, proton carrier)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7352| accessdate = }}</ref> |
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== Structure == |
== Structure == |
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Revision as of 23:59, 11 February 2015
Template:PBB Mitochondrial uncoupling protein 3 is a protein that in humans is encoded by the UCP3 gene.[1][1][2][2]
Function
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH− are not known.[3]
Structure
UCPs contain the three homologous protein domains of MACPs.[3]
Gene regulation
This gene has tissue-specific transcription initiation with other transcription initiation sites upstream of SM-1 (major skeletal muscle site). Chromosomal order is 5'-UCP3-UCP2-3'. Two splice variants have been found for this gene.[3]
Disease association
Mutations in the UCP3 gene are associated with obesity.[4][5]
Interactions
UCP3 has been shown to interact with YWHAQ.[6]
See also
References
- ^ a b Boss O, Giacobino JP, Muzzin P (April 1998). "Genomic structure of uncoupling protein-3 (UCP3) and its assignment to chromosome 11q13". Genomics. 47 (3): 425–6. doi:10.1006/geno.1997.5135. PMID 9480760. Cite error: The named reference "pmid9480760" was defined multiple times with different content (see the help page).
- ^ a b Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB (July 1997). "UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue". Biochem Biophys Res Commun. 235 (1): 79–82. doi:10.1006/bbrc.1997.6740. PMID 9196039. Cite error: The named reference "pmid9196039" was defined multiple times with different content (see the help page).
- ^ a b c "Entrez Gene: UCP3 uncoupling protein 3 (mitochondrial, proton carrier)".
- ^ Argyropoulos G, Brown AM, Willi SM, Zhu J, He Y, Reitman M, Gevao SM, Spruill I, Garvey WT (October 1998). "Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes". J. Clin. Invest. 102 (7): 1345–51. doi:10.1172/JCI4115. PMC 508981. PMID 9769326.
- ^ Dalgaard LT, Sørensen TI, Drivsholm T, Borch-Johnsen K, Andersen T, Hansen T, Pedersen O (March 2001). "A prevalent polymorphism in the promoter of the UCP3 gene and its relationship to body mass index and long term body weight change in the Danish population". J. Clin. Endocrinol. Metab. 86 (3): 1398–402. doi:10.1210/jc.86.3.1398. PMID 11238538.
- ^ Pierrat B, Ito M, Hinz W, Simonen M, Erdmann D, Chiesi M, Heim J (May 2000). "Uncoupling proteins 2 and 3 interact with members of the 14.3.3 family". Eur. J. Biochem. 267 (9): 2680–7. doi:10.1046/j.1432-1327.2000.01285.x. PMID 10785390.
Further reading
- Ricquier D, Bouillaud F (2000). "The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP". Biochem. J. 345 (2): 161–79. doi:10.1042/0264-6021:3450161. PMC 1220743. PMID 10620491.
- Muzzin P (2002). "The uncoupling proteins". Ann. Endocrinol. (Paris). 63 (2 Pt 1): 106–10. PMID 11994670.
- Boss O, Samec S, Paoloni-Giacobino A, Rossier C, Dulloo A, Seydoux J, Muzzin P, Giacobino JP (1997). "Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression". FEBS Lett. 408 (1): 39–42. doi:10.1016/S0014-5793(97)00384-0. PMID 9180264.
- Gong DW, He Y, Karas M, Reitman M (1997). "Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin". J. Biol. Chem. 272 (39): 24129–32. doi:10.1074/jbc.272.39.24129. PMID 9305858.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - Solanes G, Vidal-Puig A, Grujic D, Flier JS, Lowell BB (1997). "The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts". J. Biol. Chem. 272 (41): 25433–6. doi:10.1074/jbc.272.41.25433. PMID 9325252.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - Urhammer SA, Dalgaard LT, Sørensen TI, Tybjaerg-Hansen A, Echwald SM, Andersen T, Clausen JO, Pedersen O (1998). "Organisation of the coding exons and mutational screening of the uncoupling protein 3 gene in subjects with juvenile-onset obesity". Diabetologia. 41 (2): 241–4. doi:10.1007/s001250050897. PMID 9498661.
- Argyropoulos G, Brown AM, Willi SM, Zhu J, He Y, Reitman M, Gevao SM, Spruill I, Garvey WT (1998). "Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes". J. Clin. Invest. 102 (7): 1345–51. doi:10.1172/JCI4115. PMC 508981. PMID 9769326.
- Acín A, Rodriguez M, Rique H, Canet E, Boutin JA, Galizzi JP (1999). "Cloning and characterization of the 5' flanking region of the human uncoupling protein 3 (UCP3) gene". Biochem. Biophys. Res. Commun. 258 (2): 278–83. doi:10.1006/bbrc.1999.0530. PMID 10329378.
- Vidal-Puig AJ, Grujic D, Zhang CY, Hagen T, Boss O, Ido Y, Szczepanik A, Wade J, Mootha V, Cortright R, Muoio DM, Lowell BB (2000). "Energy metabolism in uncoupling protein 3 gene knockout mice". J. Biol. Chem. 275 (21): 16258–66. doi:10.1074/jbc.M910179199. PMID 10748196.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - Jezek P, Urbánková E (2000). "Specific sequence of motifs of mitochondrial uncoupling proteins". IUBMB Life. 49 (1): 63–70. doi:10.1080/713803586. PMID 10772343.
- Pierrat B, Ito M, Hinz W, Simonen M, Erdmann D, Chiesi M, Heim J (2000). "Uncoupling proteins 2 and 3 interact with members of the 14.3.3 family". Eur. J. Biochem. 267 (9): 2680–7. doi:10.1046/j.1432-1327.2000.01285.x. PMID 10785390.
- Clapham JC, Arch JR, Chapman H, Haynes A, Lister C, Moore GB, Piercy V, Carter SA, Lehner I, Smith SA, Beeley LJ, Godden RJ, Herrity N, Skehel M, Changani KK, Hockings PD, Reid DG, Squires SM, Hatcher J, Trail B, Latcham J, Rastan S, Harper AJ, Cadenas S, Buckingham JA, Brand MD, Abuin A (2000). "Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean". Nature. 406 (6794): 415–8. Bibcode:2000Natur.406..415C. doi:10.1038/35019082. PMID 10935638.
{{cite journal}}: Unknown parameter|author-separator=ignored (help) - Esterbauer H, Oberkofler H, Krempler F, Strosberg AD, Patsch W (2000). "The uncoupling protein-3 gene is transcribed from tissue-specific promoters in humans but not in rodents". J. Biol. Chem. 275 (46): 36394–9. doi:10.1074/jbc.M005713200. PMID 10958796.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - Lanouette CM, Chagnon YC, Rice T, Pérusse L, Muzzin P, Giacobino JP, Gagnon J, Wilmore JH, Leon AS, Skinner JS, Rao DC, Bouchard C (2002). "Uncoupling protein 3 gene is associated with body composition changes with training in HERITAGE study". J. Appl. Physiol. 92 (3): 1111–8. doi:10.1152/japplphysiol.00726.2001. PMID 11842047.
{{cite journal}}: Unknown parameter|doi_brokendate=ignored (|doi-broken-date=suggested) (help) - Collins P, Bing C, McCulloch P, Williams G (2002). "Muscle UCP-3 mRNA levels are elevated in weight loss associated with gastrointestinal adenocarcinoma in humans". Br. J. Cancer. 86 (3): 372–5. doi:10.1038/sj.bjc.6600074. PMC 2375209. PMID 11875702.
- Hu X, Murphy F, Karwautz A, Li T, Freeman B, Franklin D, Giotakis O, Treasure J, Collier DA (2002). "Analysis of microsatellite markers at the UCP2/UCP3 locus on chromosome 11q13 in anorexia nervosa". Mol. Psychiatry. 7 (3): 276–7. doi:10.1038/sj.mp.4001044. PMID 11920154.
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