Clobenpropit
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IUPAC name
N'-[(4-chlorophenyl)methyl]-1-[3-(3H-imidazol-4-yl)propylthio]formamidine
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3D model (JSmol)
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PubChem CID
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CompTox Dashboard (EPA)
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Properties | |
C14H17ClN4S | |
Molar mass | 308.82958 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Clobenpropit is a histamine H3 antagonist.[1] It has neuroprotective effects via stimulation of GABA release in the brain.[2]
References
- ^ Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P (2007). "The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes". Eur. J. Pharmacol. 567 (3): 206–10. doi:10.1016/j.ejphar.2007.04.032. PMID 17537431.
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: CS1 maint: multiple names: authors list (link) - ^ Dai H, Fu Q, Shen Y, Hu W, Zhang Z, Timmerman H, Leurs R, Chen Z. The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons. European Journal of Pharmacology. 2007 Jun 1;563(1-3):117-23. PMID 17350613