Radicicol: Difference between revisions

Radicicol
Names
	IUPAC name (1aR,2E,4E,14R,15aR)-8-chloro-9,11-dihydroxy-14-methyl-1a,14,15,15a-tetrahydro-6H-oxireno[e][2]benzoxacyclotetradecine-6,12(7H)-dione
Identifiers
CAS Number	12772-57-5 ;
3D model (JSmol)	Interactive image;
ChemSpider	16735913 ;
ECHA InfoCard	100.170.695
PubChem CID	6323491;
CompTox Dashboard (EPA)	DTXSID2042692 ;
	InChI InChI=1S/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3- Key: WYZWZEOGROVVHK-HZDAAVBUSA-N ; Key: WYZWZEOGROVVHK-HZDAAVBUBT; Key: WYZWZEOGROVVHK-HZDAAVBUSA-N;
	SMILES O=C1\C=C\C=C/C3OC3CC(C)OC(=O)c2c(O)cc(O)c(Cl)c2C1;
Properties
Chemical formula	C18H17ClO6
Molar mass	364.78 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

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Revision as of 13:18, 9 March 2011

Radicicol, also known as monorden, is a natural product that binds to Hsp90 (Heat Shock Protein 90) and alters its function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis.

Winssinger N, Barluanga S (2005). "Chemistry and biology of resorcylic acid lactones". Chem Commun. 13 (1): 22–36. doi:10.1049/b610344h. PMC 2529160. PMID 17277252. {{cite journal}}: Unknown parameter |month= ignored (help) Review of the chemistry and biology of resorcylic acid lactones, including radicicol.

This biochemistry article is a stub. You can help Wikipedia by expanding it.

@@ Line 7: / Line 7: @@
 | Section1 = {{Chembox Identifiers
 | Abbreviations =
-| InChI = 1/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3-
+| InChI = 1S/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3-
 | InChIKey = WYZWZEOGROVVHK-HZDAAVBUBT
 | StdInChI_Ref = {{stdinchicite|correct|chemspider}}
@@ Line 13: / Line 13: @@
 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
 | StdInChIKey = WYZWZEOGROVVHK-HZDAAVBUSA-N
+| InChIKey1 = WYZWZEOGROVVHK-HZDAAVBUSA-N
 | CASNo = 12772-57-5
 | CASNo_Ref ={{cascite|??|??}}

Revision as of 13:18, 9 March 2011

Further reading