Streptomyces toxytricini

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Streptomyces toxytricini
Scientific classification
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S. toxytricini
Binomial name
Streptomyces toxytricini
Preobrazhenskaya & Sveshnikova 1957

Streptomyces toxytricini is a Gram-positive bacterium belonging to the genus Streptomyces. It produces the pancreatic lipase inhibitor lipstatin,[1] of which the antiobesity drug orlistat is a derivative.[2]

References

  1. ^ Weibel E, Hadvary P, Hochuli E, Kupfer E, Lengsfeld H (1987). "Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity". J Antibiot (Tokyo). 40 (8): 1081–5. doi:10.7164/antibiotics.40.1081. PMID 3680018.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ Barbier P, Schneider F (1987). "Syntheses of tetrahydrolipstatin and absolute configuration of tetrahydrolipstatin and lipstatin". Helvetica Chimica Acta. 70 (1): 196–202. doi:10.1002/hlca.19870700124.

Further Reading

Zhu, Tingheng; Wang, Lingfei; Wang, Weixia; Hu, Zhongce; Yu, Meilan; Wang, Kun; Cui, Zhifeng (April 3, 2014). "Enhanced production of lipstatin from Streptomyces toxytricini by optimizing fermentation conditions and medium". Journal of General and Applied Microbiology. 60 (3): 106-111. doi:10.2323/jgam.60.106. PMID 25008166. Retrieved 10 November 2014.