Streptomyces
Streptomyces | ||||||||||||
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Streptomyces sp. |
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Streptomyces | ||||||||||||
Waksman & Henrici 1943 | ||||||||||||
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Streptomyces is a very species-rich genus of Actinobacteria . The species in this genus are gram-positive , aerobic , mycelium- forming, multicellular, form spores and have a high GC content . They occur mainly in soils , where they form fragrances, especially geosmin , with the characteristic odor of the forest soil. Numerous Streptomyces species produce antibiotics that are used in human and veterinary medicine.
features
Appearance
The representatives of the genus Streptomyces are gram-positive bacteria. As with many representatives of the Actinomycetales order , Streptomyces also develops cells in the form of filaments. These elongated and branched cells form plexuses, which are also known as mycelium . The filaments have a diameter of 0.5 to 1.0 µm and often no transverse walls in the growth phase.
Similar to fungi , a distinction can be made between two types of growth of Streptomyces : The substrate mycelium , which spreads in the liquid or solid nutrient medium, and the aerial mycelium that grows into the gas space above. In older cultures, transverse walls are again formed in the cell walls at the ends of the filaments of the aerial mycelium, so that chains of several, mostly spherical spores are formed by segmentation . These spores, which are to be regarded as bacterial exospores , therefore differ fundamentally from the endospores , which z. B. be formed by the bacterial genera Clostridium and Bacillus .
Chemotaxonomic Features
As a representative of the Actinomycetales in the Actinobacteria department , Streptomyces is one of the bacteria with a high GC content , ie a high proportion of the nucleobases guanine and cytosine in the bacterial DNA . Genetic studies have shown a GC content of 69 to 75 mole percent.
The complete genome of Streptomyces coelicolor was sequenced and published in 2002. The genome of Streptomyces avermitilis has also been sequenced. It contains most of the genes of all bacteria examined so far. Another feature that is rare for prokaryotes is that the chromosome is linear rather than circular. The genome of the species examined so far is extraordinarily large for bacteria, the genome size of the bacterial chromosome in Streptomyces coelicolor is 8668 kilobase pairs (kb), which is almost twice the genome size of Escherichia coli (4600 kb).
Growth and metabolism
The representatives of the genus Streptomyces are aerobic , so they need oxygen for their growth. Furthermore, they are characterized by a pronounced secondary metabolism . They produce a large number of antibiotics that are used in medicine. The antibiotic streptomycin, which is rarely used today, is named after the genus Streptomyces .
Occurrence and meaning
Streptomyces occurs mainly in soils . Many species form fragrances, especially geosmin , with the characteristic odor of the forest soil.
The many Streptomyces species that produce antibiotics are important for human and veterinary medicine . In addition, Streptomyces avidinii produces the biotin- binding protein streptavidin . Similar compounds were isolated from Streptomyces venezuelae and are designated as streptavidin v1 and v2. Compared to the amino acid sequence of the protein streptavidin, one or nine amino acids are changed. Cobalamins can be obtained as a by-product of the production of streptomycin from Streptomyces griseus .
Streptomyces rarely occurs as a pathogen, in humans Streptomyces somaliensis and " Streptomyces sudanensis " are relevant. In plants, Streptomyces caviscabies and Streptomyces scabiei (previously incorrectly referred to as Streptomyces scabies ) cause the potato scab . The systematics of some of these species is controversial.
Systematics
The genus Streptomyces is very species-rich. Currently (as of 2013) more than 600 species and subspecies are known. In the bacteria database kept as a reference for the systematics of bacteria , the species are divided into three files. Streptomyces albus is the type species of the genus.
Antibiotic producers
Here are some examples of species that are important as antibiotic producers:
- Streptomyces achromogenes produces streptozotocin
- Streptomyces ambofaciens produces spiramycin
- Streptomyces aureofaciens produces tetracycline and chlortetracycline
- Streptomyces avermitilis produces avermectins
- Streptomyces capreolus produces capreomycin
- Streptomyces carcinostaticus produces neocarcinostatin
- Streptomyces cervinus produces cervinomycin
- Streptomyces clavuligerus produces clavulanic acid , cephalosporin C and other cephalosporins as well as penicillins such as penicillin G or penicillin N.
- Streptomyces coeruleorubidus produces daunorubicin
- Streptomyces davawensis produces roseoflavin
- Streptomyces fradiae produces neomycin , tylosin
- Streptomyces griseus (among others) produces streptomycin
- Streptomyces hygroscopicus produces hygromycin B
- Streptomyces lavendulae produces fosmidomycin , lavendamycin, and mitomycin C.
- Streptomyces lincolnensis produces clindamycin
- Streptomyces natalensis produces natamycin
- Streptomyces nodosus produces amphotericin B.
- Streptomyces noursei produces nystatin
- Streptomyces olivaceus produces granaticin
- Streptomyces peuceticus produces daunorubicin
- Streptomyces platensis produces Platensimycin
- Streptomyces rimosus produces paromomycin
- Streptomyces spectabilis produces spectinomycin
- Streptomyces toxytricini produces lipstatin
- Streptomyces venezuelae produces chloramphenicol
- Streptomyces violaceoniger produces lysolipin
- Streptomyces violaceoruber produces Granaticin
Changed system
The delimitation of the numerous Streptomyces species from one another is quite controversial. Studies from 2005 showed that the species Streptomyces caviscabies Goyer et al. 1996 coincides with the already known species Streptomyces griseus ( Krainsky 1914) Waksman & Henrici 1948 and therefore has to be renamed. This was confirmed in 2008 by studies by Guo et al. refuted. Investigations from 2010 showed that it is instead identical to the already known species Streptomyces fimicarius ( Duché 1934) Waksman & Henrici 1948. This species was then discovered in 2012 by Kim et al. identified as a synonym of Streptomyces setonii , so that according to the current system it is now Streptomyces setonii ( Millard & Burr 1926) Waksman 1953 emend. Kim et al. 2012 acts.
By molecular biological studies is checked whether the variety of species inventory, or whether some species are so closely related to each other that they become a kind - should be combined - possibly with subspecies. The methods used in an investigation from 2010 include DNA – DNA hybridization and multi- locus sequence analysis (MLSA). The hybridization technique serves to demonstrate the structural relationship of nucleic acids and thus to elucidate the phylogenetic relationship. In the MLSA, the investigation is limited to certain genes that are particularly typical of a species or genus. Sequence analysis of the 2010 was limited to the detection of five housekeeping genes (English housekeeping genes , non-regulated genes regardless of cell type, cell stage and external influences expressed are). As a result of the investigation, it was proposed to combine the 29 species and three subspecies on which the investigation was based into only eleven species.
The species " Streptomyces sudanensis ", which is significant for human medicine, has not yet been published in accordance with the rules of the International Code of Nomenclature of Bacteria (ICNB) and is therefore placed in quotation marks. The bacterial strains examined are closely related to Streptomyces somaliensis .
See also
Web links
swell
literature
- Martin Dworkin, Stanley Falkow , Eugene Rosenberg, Karl-Heinz Schleifer , Erko Stackebrandt (eds.): The Prokaryotes. A Handbook on the Biology of Bacteria . 3. Edition. tape 3 : Archaea. Bacteria: Firmicutes, Actinomycetes . Springer-Verlag, New York 2006, ISBN 0-387-30743-5 , doi : 10.1007 / 0-387-30743-5 .
Individual evidence
- ↑ a b c d e f g h i j k l m Michael T. Madigan, John M. Martinko, Jack Parker: Brock Mikrobiologie. German translation edited by Werner Goebel, 1st edition. Spectrum Akademischer Verlag GmbH, Heidelberg / Berlin 2000, ISBN 978-3-8274-0566-1 , pp. 440-441, 577-582.
- ↑ a b S. D. Bentley, KF Chater u. a .: Complete genome sequence of the model actinomycete Streptomyces coelicolor A3 (2). In: Nature . Volume 417, No. 6885, May 2002, pp. 141-147, ISSN 0028-0836 . doi: 10.1038 / 417141a . PMID 12000953 .
- ↑ J. Altenbuchner, M. Redenbach: Why do some bacteria have linear chromosomes and plasmids? (PDF) BIOspektrum 2/2002, pp. 158–163.
- ↑ a b E. A. Bayer, T. Kulik, R. Adar, M. Wilchek: Close similarity among streptavidin-like, biotin-binding proteins from Streptomyces. In: Biochimica et Biophysica Acta . Volume 1263, No. 1, July 1995, pp. 60-66, ISSN 0006-3002 . PMID 7632734 .
- ↑ H. Hager, F. v. Bruchhausen, R. Batty, G. Wurm: Hager's handbook of pharmaceutical practice. 5th edition, volume 1 Goods and Services , Springer, 1995, ISBN 978-3-540-58958-7 , p. 37.
- ↑ a b E. T. Quintana, K. Wierzbicka u. a .: Streptomyces sudanensis sp. nov., a new pathogen isolated from patients with actinomycetoma In: Antonie van Leeuwenhoek. Volume 93, Number 3, March 2008, pp. 305-313, ISSN 0003-6072 . doi: 10.1007 / s10482-007-9205-z
- ^ A b c d Jean Euzéby, Aidan C. Parte: Genus Streptomyces File 3. In: List of Prokaryotic names with Standing in Nomenclature ( LPSN ). Retrieved December 23, 2013 .
- ↑ DH Lambert, R. Loria: Streptomyces scabies sp. nov., nom. rev. In: International Journal of Systematic Bacteriology. Volume 39, Number 4, October 1989, pp. 387-392, ISSN 0020-7713 . doi: 10.1099 / 00207713-39-4-387 .
- ^ A b Prokaryotic Nomenclature Up-to-date. In: Website of the Leibniz Institute DSMZ - German Collection of Microorganisms and Cell Cultures GmbH . Retrieved December 23, 2013 .
- ↑ a b c Jean Euzéby, Aidan C. Part: Genus Streptomyces File 1. In: List of Prokaryotic names with Standing in Nomenclature ( LPSN ). Retrieved December 23, 2013 .
- ↑ Jean Euzéby, Aidan C. Parte: Genus Streptomyces File 2. In: List of Prokaryotic names with Standing in Nomenclature ( LPSN ). Retrieved December 23, 2013 .
- ↑ A. Nagakawa, S. Omura: Structure of Cervinomycine, a novel Xantone Antibiotic against Anaerobe and Mycoplasma. In: Journal of Antibiotics . Pp. 301-308, Vol. XL, No. 3, August 30, 1986, doi: 10.7164 / antibiotics.40.301 .
- ↑ C. Reading, M. Cole: Clavulanic acid: a beta-lactamase-inhiting beta-lactam from Streptomyces clavuligerus. In: Antimicrobial agents and chemotherapy. Volume 11, Number 5, May 1977, pp. 852-857, PMID 879738 , PMC 352086 (free full text).
- ↑ a b C. E. Higgens, RE Kastner: Streptomyces clavuligerus sp. nov., a β-Lactam Antibiotic Producer. In: International Journal of Systematic and Evolutionary Bacteriology. Volume 21, Number 4, October 1971, pp. 326-331, doi : 10.1099 / 00207713-21-4-326 .
- ↑ Entry on Mitomycins. In: Römpp Online . Georg Thieme Verlag, accessed on April 26, 2011.
- ↑ Entry on lavendamycin. In: Römpp Online . Georg Thieme Verlag, accessed on April 26, 2011.
- ^ H. Drautz, W. Keller-Schierlein, H. zahner: metabolic products of microorganisms. In: Archives of Microbiology. Pp. 175-190, Volume 106, No. 3 / January 1975.
- ↑ X. Rong, Y. Huang: Taxonomic evaluation of the Streptomyces griseus clade using multilocus sequence analysis and DNA-DNA hybridization, with proposal to combine 29 species and three subspecies as 11 genomic species. In: International journal of systematic and evolutionary microbiology. Volume 60, No. 3, March 2010, pp. 696-703, ISSN 1466-5026 . doi: 10.1099 / ijs.0.012419-0 . PMID 19656940 .