Zinostatin
Structural formula | |||||||||||||
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Neocarzinostatin Chromophore | |||||||||||||
General | |||||||||||||
Non-proprietary name | Zinostatin (INN) | ||||||||||||
other names |
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Molecular formula | C 35 H 33 NO 12 | ||||||||||||
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Drug information | |||||||||||||
Drug class |
Cytostatic |
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properties | |||||||||||||
Molar mass | |||||||||||||
Physical state |
firmly |
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Melting point |
260 ° C (decomposition) |
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solubility |
soluble in water |
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safety instructions | |||||||||||||
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Toxicological data | |||||||||||||
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Zinostatin (also: Neocarzinostatin ) is a drug from the group of enediyne - antibiotics with an antineoplastic effect. Responsible for the antitumor effect is a chromophoric part that is non- covalently bound to an apoprotein consisting of 113 amino acids . The chromophore is chemically unstable without binding to the peptide. The peptide consists of a single chain. Zinostatin is obtained from cultures of Streptomyces carcinostaticus var. F-41 . The neocarzinostatin chromophore causes strand breaks in the DNA , preferably in the deoxyribose of thymine .
The conjugate of zinostatin with styrene-maleic acid copolymer was used in Japan for the treatment of hepatocellular carcinoma until 2009 .
Individual evidence
- ↑ a b The Merck Index . An Encyclopaedia of Chemicals, Drugs and Biologicals . 14th edition, 2006, p. 1750, ISBN 978-0-911910-00-1 .
- ↑ a b Datasheet Neocarzinostatin from Streptomyces carzinostaticus from Sigma-Aldrich , accessed on February 3, 2018 ( PDF ).
- ↑ a b c d e Entry on Neocarzinostatine. In: Römpp Online . Georg Thieme Verlag, accessed on August 22, 2011.
- ↑ Pharmaceutical Substance List, 12th Edition 2001, Advertising and Sales Association of German Pharmacists.