Budget gen

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A housekeeping gene (also English housekeeping gene , non-regulated gene , constitutively expressed gene ) is a gene which, regardless of cell type, cell stage and external influences expressed will, in contrast to the regulated genes .

Household genes are typically genes that encode the structural molecules and enzymes that are related to the basic metabolism of cells, such as glucose metabolism .

They often do not contain a TATA box , but do contain CAAT or GC boxes .

Household genes of humans

Gene expression

Transcription factors

SREBP Sterol Regulatory Element Binding Protein
Repressors

Splice

Small nuclear ribonucleoprotein-associated proteins B and B '

Translation factors

tRNA synthetases

Genes that code for aminoacyl-tRNA synthetases , including mitochondrial ones (2):

  • EARS2 glutamyl-tRNA synthetase 2, mitochondrial (suggested) NM_001083614
  • EPRS Bifunctional Glutamyl / Prolyl-tRNA Synthetase
  • PARS2 prolinyl-tRNA synthetase 2, mitochondrial (proposed)
  • TARS tryptophanyl tRNA synthetase
  • WARS2 tryptophanyl tRNA synthetase 2, mitochondrial NM_015836
RNA binding proteins

Ribosomal Proteins

RNA polymerases

Protein processing

Heat shock proteins

Histones

Cell cycle

Apoptosis

Oncogenes

DNA repair and replication

  • Ku80 synonymous with XRCC5
  • MCM3AP presumably a primase

metabolism

  • PRKAG1 inactivates HMGCoA reductase and acetyl-CoA carboxylase

Carbohydrate metabolism

Citric acid cycle

Fat metabolism

  • GM2A low expression
  • HADHA trifunctional protein subunit α
  • HADHB trifunctional protein subunit β

Amino acid metabolism

Nucleotide synthesis

  • IMPDH2 guanine nucleotide biosynthesis

NADH dehydrogenases

Cytochrome C oxidases

(COX1, COX2 and COX3 are coded in the mitochondrion)

ATPases

Mitochondrial
Lysosomal

Lysosome

Proteasome

Ribonuclease

  • RNH ribonuclease inhibitor

Oxidase / reductase

  • TXN thioreductase

Structural proteins

Cytoskeleton

Organelle synthesis

A special form of cell signaling

Mitochondrion

Cell surface

Cell adhesion

Canals and vans

Receptors

HLA, immunoglobulins and cell recognition

Kinases and signal transduction

Growth factors

Tissue necrosis factors

  • CD40 formerly TNFRSF5

Casein kinases

various

Open reading frames

Limited to sperm or testicles

Individual evidence

  1. ↑ Jan Koolman, Klaus-Heinrich Röhm: Pocket Atlas of Human Biochemistry . 2009, ISBN 978-3-13-759404-8 ( page 242 in the Google book search).
  2. ↑ H. Robert Horton, Laurence A. Moran, K. Gray Scrimgeour, J. David Rawn, Marc D. Perry: Biochemistry . 2008, ISBN 978-3-8273-7312-0 ( page 860 in the Google book search).
  3. ↑ Detlev Ganten, Klaus Ruckpaul: Fundamentals of molecular medicine . Springer, 2007, ISBN 978-3-540-69412-0 ( page 121 in the Google book search).
  4. ↑ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as at au av aw ax ay az ba bb bc bd be bf bg bh bi bj bk bl bm bn bo bp bq br bs bt bu bv bw bx by bz ca cb cc cd ce cf cg ch ci cj ck cl cm cn co cp cq cr cs ct cu cv cw cx cy cz da db dc dd de df dg dh di dj dk dl dm dn do dp dq dr ds dt du dv dw dx dy dz ea eb ec ed ee ef eg eh ei ej ek el em en eo ep eq er es et eu ev ew ex ey ez fa fb fc fd fe ff fg fh fi fj fk fl fm fn fo fp fq fr fs ft fu fv fw fx fy fz ga gb gc gd ge gf gg gh gi gj gk gl gm gn go gp gq gr gs gt gu gv gw gx gy gz ha hb hc hd he hf hg hh hi hj hk hl hm hn ho hp hq hr hs ht hu hv hw hx hy hz ia ib ic id ie if ig ih ii ij ik il im in io ip iq ir is it iu iv iw ix iy iz ja jb jc jd je jf jg jh ji jj jk jl jm jn jo jp jq jr js jt ju jv jw jx jy jz ka kb kc kd ke kf kg kh ki kj kk kl km kn ko kp kq kr ks kt ku kv kw kx ky kz la lb lc ld le lf lg lh li lj lk ll lm ln lo lp lq lr Eisenberg E, and Levanon EY: Human housekeeping genes are compact . In: TRENDS in Genetics . 19, No. 7, July 2003, pp. 362-365. doi : 10.1016 / S0168-9525 (03) 00140-9 . PMID 12850439 .
  5. ↑ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as at au av aw ax ay az ba bb bc bd be bf bg bh bi bj bk bl bm bn bo bp bq br bs bt bu bv bw bx by bz ca cb cc cd ce cf cg ch ci cj ck cl cm cn co cp cq cr cs ct cu cv cw cx cy cz da db dc dd de df dg dh di dj dk dl dm dn do dp dq dr ds dt du dv dw dx dy dz ea eb ec ed ee ef Velculescu VE, Madden SL, Zhang L, Lash AE, Yu J, Rago C, Lal A, Wang CJ, Beaudry GA, Ciriello KM, Cook BP, Dufault MR, Ferguson AT, Gao Y, He TC, Hermeking H, Hiraldo SK, Hwang PM, Lopez MA, Luderer HF, Mathews B, Petroziello JM, Polyak K, Zawel L, Zhang W, Zhang X, Zhou W, Haluska FG, Jen J, Sukumar S, Landes GM, Riggins GJ, Vogelstein B, Kinzler KW .: Analyzes of Human Transcriptomes . In: Nat Genet . 23, No. 4, December 1999, pp. 387-388. doi : 10.1038 / 70487 . PMID 10581018 .
  6. ↑ a b c d e f g h i j k l Caradec J, Sirab N, Keumeugni C, et al ..: 'Desperate house genes': the dramatic example of hypoxia . In: British Journal of Cancer . 102, No. 6, 2010, pp. 1037-43. doi : 10.1038 / sj.bjc.6605573 . PMID 20179706 . PMC 2844028 (free full text).
  7. ↑ Hsiao LL, Dangond F, Yoshida T, Hong R, Jensen RV, Misra J, Dillon W, Lee KF, et al .: A compendium of gene expression in normal human tissues . In: Physiol Genomics . 7, No. 2, pp. 97-104. doi : 10.1152 / physiolgenomics.00040.2001 . PMID 11773596 .
  8. ↑ Susanne Walz, Francesca Lorenzin, Jennifer Morton, Katrin E. Wiese, Björn von Eyss: Activation and repression by oncogenic MYC shape tumor-specific gene expression profiles . In: Nature . tape 511 , no. 7510 , July 2014, ISSN  0028-0836 , p. 483-487 , doi : 10.1038 / nature13473 , PMID 25043018 ( nature.com [accessed May 12, 2020]).