Dopachrome tautomerase
| Dopachrome tautomerase | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 498 amino acids | |
| Secondary to quaternary structure | Membrane protein | |
| Cofactor | 2 zinc | |
| Identifier | ||
| Gene names | DCT ; TYRP2 | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 5.3.3.12 , isomerase | |
| Response type | Rearrangement | |
| Substrate | Dopachrome | |
| Products | DHICA | |
| Occurrence | ||
| Homology family | Tyrosinase | |
| Parent taxon | Chordates | |
| Orthologue | ||
| human | House mouse | |
| Entrez | 1638 | 13190 |
| Ensemble | ENSG00000080166 | ENSMUSG00000022129 |
| UniProt | P40126 | P29812 |
| Refseq (mRNA) | NM_001129889 | NM_010024 |
| Refseq (protein) | NP_001123361 | NP_034154 |
| Gene locus | Chr 13: 94.44 - 94.48 Mb | Chr 14: 118.01 - 118.05 Mb |
| PubMed search | 1638 |
13190
|
Dopachrome tautomerase (Dct) ( gene : DCT ) is the name of the enzyme that converts dopachrome to 5,6-dihydroxyindole-2-carboxylate (DHICA). This reaction step belongs to one of two metabolic pathways for the production of the pigment melanin . Mutations in the DCT gene can affect hair color.
Dct is similar to tyrosinase and DHICA oxidase , but instead of copper it has two zinc atoms as the catalytic center. DCT is overly dominant in Europeans . Dct is not only a marker for melanoblasts , but it also regulates the sprouting of neuronal progenitor cells.
Catalyzed reaction
-
⇒ 
- Dopachrome is rearranged to DHICA.
Individual evidence
- ↑ UniProt P40126 .
- ^ Dopachrome tautomerase. In: Online Mendelian Inheritance in Man . (English).
- ↑ Alonso S, Izagirre N, Smith-Zubiaga I, et al : Complex signatures of selection for the melanogenic loci TYR, TYRP1 and DCT in humans . In: BMC Evol. Biol . 8, 2008, p. 74. doi : 10.1186 / 1471-2148-8-74 . PMID 18312627 . PMC 2292700 (free full text).
- ↑ Jiao Z, Zhang ZG, Hornyak TJ, et al : Dopachrome tautomerase (Dct) regulates neural progenitor cell proliferation . In: Dev. Biol. . 296, No. 2, August 2006, pp. 396-408. doi : 10.1016 / j.ydbio.2006.06.006 . PMID 16857183 .
Web links
Wikibooks: Tyrosine Metabolism - Learning and Teaching Materials
