Basigin
| Basigin | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 364 amino acids | |
| Secondary to quaternary structure | single pass type 1 membrane protein | |
| Precursor | (385 aa) | |
| Isoforms | 2 | |
| Identifier | ||
| Gene names | BSG , CD147, HAb18G | |
| External IDs | ||
| Transporter classification | ||
| TCDB | 8.A.23.1.1 | |
| designation | Basigin family | |
| Occurrence | ||
| Parent taxon | Vertebrates | |
Basigin (also: extracellular matrix metalloproteinase inducer , shortly EMMPRIN ) is a glycoprotein in the cell membrane of epithelial cells of vertebrates . It exerts functions including in carbohydrate - metabolism and in the signaling of the immune system from. Basigin carries an immunoglobulin (Ig) protein domain and is a determinant of the OK blood group system . In humans, it is mainly expressed in the vascular epithelium and in malignant gliomas .
Basigin is responsible for localizing the monocarboxylate transporters MCT1 , MCT4 and MCT12, whose subsequent transport activity is impossible without binding to basigin. Basigin is therefore indispensable for the exchange of lactate between cells.
With the help of the Ig domain, basin in one cell binds to basin in a neighboring cell and thus acts as a cell adhesion molecule . Basigin also binds integrins , cyclophilins , caveolin -1 and annexin II . Its cytosolic domain induces the expression of matrix metalloproteases (MMP) and is therefore part of angiogenesis , cell proliferation , energy metabolism , cell migration and cell motility .
In addition to its physiological importance Basigin plays an important role in the formation of by Plasmodium falciparum induced malaria tropica. The parasite uses Basigin as a receptor to attend erythrocytes penetrate and bind into it. Basigin may also serve as a portal of entry into host cells for the SARS-CoV-2 coronavirus (in addition to ACE2 ). An antibody directed against CD147, meplazumab , was successfully tested against COVID-19 pneumonia in patients.
Web links
- de Bono / Garapati / reactome: Basigin interactions
- d'Eustachio / reactome: lactate + H + [cytosol] <=> lactate + H + [extracellular]
Individual evidence
- ↑ Orthologist at OMA
- ↑ UniProt P35613
- ↑ Wilson MC, Meredith D, Fox JE, Manoharan C, Davies AJ, Halestrap AP: Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70) . In: J. Biol. Chem. . 280, No. 29, July 2005, pp. 27213-21. doi : 10.1074 / jbc.M411950200 . PMID 15917240 .
- ↑ Jiang JL, Tang J: CD147 and its interacting proteins in cellular functions . In: Sheng Li Xue Bao . 59, No. 4, August 2007, pp. 517-23. PMID 17700972 .
- ↑ C. Crosnier, LY Bustamante, SJ Bartholdson, AK Bei, M. Theron, M. Uchikawa, S. Mboup, O. Ndir, DP Kwiatkowski, MT Duraisingh, JC Rayner, GJ Wright: Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum. In: Nature . Volume 480, number 7378, November 2011, pp. 534-537, doi : 10.1038 / nature10606 , PMID 22080952 , PMC 3245779 (free full text).
- ↑ Ke Wang et al .: SARS-CoV-2 invades host cells via a novel route: CD147-spike protein. BioRxiv (preprint), 2020-03-14, doi : 10.1101 / 2020.03.14.988345
- ↑ Bian H, Zheng ZH, Wei D, Zhang Z, Kang WZ, Hao CQ, et al. (2020). " Meplazumab treats COVID-19 pneumonia: an open-labeled, concurrent controlled add-on clinical trial ". BioRxiv , 2020-03-24, doi: 10.1101 / 2020.03.21.20040691