Monocarboxylate transporter 1
Monocarboxylate transporter 1 | ||
---|---|---|
Properties of human protein | ||
Mass / length primary structure | 500 amino acids | |
Secondary to quaternary structure | multipass (12 TMS) membrane protein | |
Identifier | ||
Gene name | SLC16A1 | |
External IDs | ||
Transporter classification | ||
TCDB | 2.A.1.13.1 | |
designation | Major Facilitator Superfamily / Monocarboxylate Porter | |
Occurrence | ||
Homology family | SLC16 | |
Parent taxon | Euteleostomi |
Monocarboxylate transporter 1 (MCT1) ( gene : SLC16A1 ) is the name of the protein in the cell membrane of vertebrate cells that catalyzes the diffusion of many monocarboxylic acids out of the cells . In particular, the transport of lactic acid from muscle cells under anaerobic conditions and from erythrocytes is indispensable in order not to over-acidify the inside of the cells . Mutations in the SLC16A1 gene in humans can lead to a lack of transporters and (more rarely, hereditary) inability to use muscles extremely; also are myoglobin and creatine kinase in the blood increases.
The catalyzed membrane transport equilibrium is:
- Monocarboxylate (inside) + H + (inside) monocarboxylate (outside) + H + (outside)
So it is a symport . Lactate , pyruvate , mevalonate , anions of branched keto acids , β-hydroxybutyrate , γ-hydroxybutyrate , butyrate , acetoacetate , acetate and anions of valine and isoleucine function as monocarboxylate .
The presence of basigin is absolutely necessary for the function of MCT1 , which as a chaperone is also responsible for the localization of MCT1. Furthermore, the transporter activity is stimulated by binding to carbonate anhydrase-2.
Individual evidence
- ↑ UniProt P53985
- ↑ TCDB : 2.A.1
- ↑ UniProt P53985 , TCDB : 2.A.1.13.1
- ↑ Wilson MC, Meredith D, Fox JE, Manoharan C, Davies AJ, Halestrap AP: Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70) . In: J. Biol. Chem. . 280, No. 29, July 2005, pp. 27213-21. doi : 10.1074 / jbc.M411950200 . PMID 15917240 .
- ↑ Becker HM, Deitmer JW: Nonenzymatic proton handling by carbonic anhydrase II during H + -lactate cotransport via monocarboxylate transporter 1 . In: J. Biol. Chem. . 283, No. 31, August 2008, pp. 21655-67. doi : 10.1074 / jbc.M802134200 . PMID 18539591 .