6-phosphogluconate dehydrogenase
6-phosphogluconate dehydrogenase | ||
---|---|---|
6-phosphogluconate dehydrogenase dimer, ovis aries according to PDB 1PGO | ||
Properties of human protein | ||
Mass / length primary structure | 482 amino acids | |
Secondary to quaternary structure | Homodimer | |
Identifier | ||
Gene names | PGD ; 6PGD | |
External IDs | ||
Enzyme classification | ||
EC, category | 1.1.1.44 , oxidoreductase | |
Response type | Decarboxylative dehydration | |
Substrate | 6-phospho-D-gluconate + NADP + | |
Products | Ribulose-5-phosphate + CO 2 + NADPH / H + | |
Occurrence | ||
Parent taxon | Creature | |
Orthologue | ||
human | House mouse | |
Entrez | 5226 | 110208 |
Ensemble | ENSG00000142657 | ENSMUSG00000028961 |
UniProt | P52209 | Q9DCD0 |
Refseq (mRNA) | NM_001304451 | NM_001081274 |
Refseq (protein) | NP_001291380 | NP_001074743 |
Gene locus | Chr 1: 10.4 - 10.42 Mb | Chr 4: 149.15 - 149.17 Mb |
PubMed search | 5226 |
110208
|
6-phosphogluconate dehydrogenase (6PGD) is the enzyme that converts 6-phosphogluconate to ribulose-5-phosphate . This reaction is the third step in the pentose phosphate pathway . 6PGD occurs in most living things.
A possible 6PGD deficiency due to defects in PGD - gene is asymptomatic, even if less than five percent of the normal amount is available on the enzyme. Bacterial 6PGD acts as an adhesin .
Catalyzed reaction
6-phosphogluconate is dehydrated to the keto acid, producing NADPH. The keto acid breaks down to ribulose-5-phosphate, releasing carbon dioxide.
Individual evidence
- ↑ UniProt P52209 , PROSITE : PROSITE documentation PDOC00390 (English)
- ↑ 6-phosphogluconate dehydrogenase. In: Online Mendelian Inheritance in Man . (English).
- ↑ Tan C, Fu S, Liu M, et al : Cloning, expression and characterization of a cell wall surface protein, 6-phosphogluconate-dehydrogenase, of Streptococcus suis serotype 2 . In: Vet. Microbiol. . 130, No. 3-4, August 2008, pp. 363-70. doi : 10.1016 / j.vetmic.2008.02.025 . PMID 18403138 .
Web links
Wikibooks: Biochemistry and Pathobiochemistry: Hexose Monophosphate Pathway - Learning and Teaching Materials