6-phosphogluconate dehydrogenase

6-phosphogluconate dehydrogenase
	6-phosphogluconate dehydrogenase dimer, ovis aries according to PDB 1PGO
Properties of human protein
Mass / length primary structure	482 amino acids
Secondary to quaternary structure	Homodimer
Identifier
Gene names	PGD ; 6PGD
External IDs	OMIM : 172200 ; UniProt : P52209 ;
Enzyme classification
EC, category	1.1.1.44 , oxidoreductase
Response type	Decarboxylative dehydration
Substrate	6-phospho-D-gluconate + NADP +
Products	Ribulose-5-phosphate + CO 2 + NADPH / H +
Occurrence
Parent taxon	Creature
	Orthologue

6-phosphogluconate dehydrogenase (6PGD) is the enzyme that converts 6-phosphogluconate to ribulose-5-phosphate . This reaction is the third step in the pentose phosphate pathway . 6PGD occurs in most living things.

A possible 6PGD deficiency due to defects in PGD - gene is asymptomatic, even if less than five percent of the normal amount is available on the enzyme. Bacterial 6PGD acts as an adhesin .

Catalyzed reaction

+ NADP ⁺ + NADPH / H ⁺ + CO ₂ ${\ displaystyle \ longrightarrow}$ ${\ displaystyle \ longrightarrow}$

6-phosphogluconate is dehydrated to the keto acid, producing NADPH. The keto acid breaks down to ribulose-5-phosphate, releasing carbon dioxide.

Individual evidence

↑ UniProt P52209 , PROSITE : PROSITE documentation PDOC00390 (English)
↑ 6-phosphogluconate dehydrogenase. In: Online Mendelian Inheritance in Man . (English).
↑ Tan C, Fu S, Liu M, et al : Cloning, expression and characterization of a cell wall surface protein, 6-phosphogluconate-dehydrogenase, of Streptococcus suis serotype 2 . In: Vet. Microbiol. . 130, No. 3-4, August 2008, pp. 363-70. doi : 10.1016 / j.vetmic.2008.02.025 . PMID 18403138 .

Web links

Wikibooks: Biochemistry and Pathobiochemistry: Hexose Monophosphate Pathway - Learning and Teaching Materials

reactome.org: 6-phospho-D-gluconate + NADP + ⇒ D-ribulose 5-phosphate + CO2 + NADPH + H +

[1] UniProt P52209 , PROSITE : PROSITE documentation PDOC00390 (English)

[2] 6-phosphogluconate dehydrogenase. In: Online Mendelian Inheritance in Man . (English).

[3] Tan C, Fu S, Liu M, et al : Cloning, expression and characterization of a cell wall surface protein, 6-phosphogluconate-dehydrogenase, of Streptococcus suis serotype 2 . In: Vet. Microbiol. . 130, No. 3-4, August 2008, pp. 363-70. doi : 10.1016 / j.vetmic.2008.02.025 . PMID 18403138 .