Transketolase
| Transketolase | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 623 amino acids | |
| Secondary to quaternary structure | Homodimer | |
| Cofactor | Calcium, thiamine pyrophosphate | |
| Identifier | ||
| Gene name | TKT | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 2.2.1.1 , transferase | |
| Response type | Transfer of a ketol group | |
| Substrate | Xylulose-5-phosphate + D- ribose-5-phosphate | |
| Products | D- glyceraldehyde-3-phosphate + sedoheptulose-7-phosphate | |
| Occurrence | ||
| Homology family | Transketolase | |
| Parent taxon | Creature | |
Transketolase (TK) (gene: TKT ) is the name for enzymes that transfer a keto group from xylulose-5-phosphate to an aldol , usually ribose-5-phosphate . This reaction step, together with that of the transaldolase , connects glycolysis with the pentose phosphate pathway . Transketolases are found in bacteria, plants and animals. Several isoforms have formed in mammals , such as transketolase-like-1 . Mutations in the TKT gene lead to a lack of transketolase activity, which together with a lack of its coenzyme thiamine (vitamin B1) leads to Wernicke-Korsakoff syndrome in alcoholics.
Catalyzed reaction
 |
Xylulose-5-phosphate | + |  |
D- ribose-5-phosphate |
|
||||
|
D- glyceraldehyde-3-phosphate | + |
|
Sedoheptulose-7-phosphate |
Individual evidence
Web links
Wikibooks: Biochemistry and Pathobiochemistry: Hexose Monophosphate Pathway - Learning and Teaching Materials
