TNFRSF5

TNFRSF5
	according to PDB 1CDF
other names	B-cell surface antigen CD40, Bp50, CD40L receptor, CDw40, CD_antigen: CD40, Tumor necrosis factor receptor superfamily member 5
	Existing structure data : PDB 1CZZ , PDB 1D00
Properties of human protein
Mass / length primary structure	277 amino acids , 30,619 Da
Secondary to quaternary structure	Monomer or homodimer
Identifier
External IDs	GeneCards : CD40 ; OMIM : 601752 ; UniProt : P25942 ;
	Orthologue (human)
Entrez	953
Ensemble	ENSG00000138185
UniProt	P25942
Refseq (mRNA)	NM_001098175.1
Refseq (protein)	NP_001091645.1
PubMed search	953

Tumor necrosis factor receptor superfamily 5 (synonymous TNFRSF 5 , CD40 ) is a surface protein from the tumor necrosis factor receptor superfamily .

properties

CD40 is a co- stimulator in B cells , dendritic cells, and some tumors . It is the receptor of TNFSF5 ( CD40L ). CD40 is involved in the activation of ERK in macrophages and B cells , whereupon antibodies are increasingly secreted in B cells . It's glycosylated .

Web links

MeSH TNFRSF5

Individual evidence

^ EA Clark: A Short History of the B-Cell-Associated Surface Molecule CD40. In: Frontiers in immunology. Volume 5, 2014, p. 472, doi : 10.3389 / fimmu.2014.00472 , PMID 25324844 , PMC 4179537 (free full text).

[1] EA Clark: A Short History of the B-Cell-Associated Surface Molecule CD40. In: Frontiers in immunology. Volume 5, 2014, p. 472, doi : 10.3389 / fimmu.2014.00472 , PMID 25324844 , PMC 4179537 (free full text).