CD81

from Wikipedia, the free encyclopedia
CD81 antigen
CD81 antigen
according to PDB  1G8Q
other names

26 kDa cell surface protein TAPA-1, Target of the antiproliferative antibody 1, Tetraspanin-28, Tspan-28

Existing structure data : PDB  1IV5 , PDB  2AVZ

Properties of human protein
Mass / length primary structure 236 amino acids , 25,809 Da
Identifier
External IDs
Orthologue (human)
Entrez 975
Ensemble ENSG00000110651
UniProt P60033
Refseq (mRNA) NM_001297649.1
Refseq (protein) NP_001284578.1
PubMed search 975

CD81 (synonymous Tspan-28 ) is a surface protein from the group of tetraspanins .

properties

CD81 is of hematopoietic , endothelial and epithelial cells formed, but also of hematopoietic, neuroectodermal and mesenchymal tumor - cell lines formed. It is not found in red blood cells , platelets, and neutrophils . CD81 is involved in the organization of the cell membrane , in protein transport , in cell fusions and in cell contacts . In the immune system , CD81 regulates the immunological synapse , the grouping of receptors in the cell membrane and reduces the immune response . CD81 binds to Leu-13 . It also binds to Tspan-4 , CD19 , CD9 , PTGFRN , CD117 and CD29 . It also binds to IGSF8 , CD316 and CD36 and forms a larger protein complex with CD19, CD21 and Leu-13 on the cell surface of B cells .

CD81 is a receptor for the hepatitis C virus and plasmodia and increases infection with Listeria . Presumably CD81 is the cellular receptor for HCMV .

CD81 is involved in the regulation of lymphoma cell growth and is used as a target in the treatment of tumors.

CD81 also binds benzyl salicylate and terfenadine .

Web links

Individual evidence

  1. ↑ a b c d F. Vences-Catalán, C. Duault, CC Kuo, R. Rajapaksa, R. Levy, S. Levy: CD81 as a tumor target. In: Biochemical Society transactions. Volume 45, number 2, April 2017, pp. 531-535, doi : 10.1042 / BST20160478 , PMID 28408492 .
  2. ↑ Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME: NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins . In: J. Biol. Chem. . 272, No. 46, November 1997, pp. 29181-9. doi : 10.1074 / jbc.272.46.29181 . PMID 9360996 .
  3. ↑ Bradbury LE, Kansas GS, Levy S, Evans RL, Tedder TF: The CD19 / CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules . In: J. Immunol. . 149, No. 9, November 1992, pp. 2841-50. PMID 1383329 .
  4. ↑ Imai T, Kakizaki M, Nishimura M, Yoshie O: Molecular analyzes of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82 . In: J. Immunol. . 155, No. 3, August 1995, pp. 1229-39. PMID 7636191 .
  5. ↑ a b Horváth G, Serru V, Clay D, Billard M, Boucheix C, Rubinstein E: CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82 . In: J. Biol. Chem. . 273, No. 46, November 1998, pp. 30537-43. doi : 10.1074 / jbc.273.46.30537 . PMID 9804823 .
  6. ↑ Radford KJ, Thorne RF, Hersey P: CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma . In: Biochem. Biophys. Res. Commun. . 222, No. 1, May 1996, pp. 13-8. doi : 10.1006 / bbrc.1996.0690 . PMID 8630057 .
  7. ↑ Charrin S, Le Naour F, Oualid M, Billard M, Faure G, Hanash SM, Boucheix C, Rubinstein E: The major CD9 and CD81 molecular partner. Identification and characterization of the complexes . In: J. Biol. Chem. . 276, No. 17, April 2001, pp. 14329-37. doi : 10.1074 / jbc.M011297200 . PMID 11278880 .
  8. ↑ Stipp CS, Orlicky D, Hemler ME: FPRP, a major, highly stoichiometric, highly specific CD81- and CD9-associated protein . In: J. Biol. Chem. . 276, No. 7, February 2001, pp. 4853-62. doi : 10.1074 / jbc.M009859200 . PMID 11087758 .
  9. ↑ N. Anzai, Y. Lee, BS Youn, S. Fukuda, YJ Kim, C. Mantel, M. Akashi, HE Broxmeyer: C-kit associated with the transmembrane 4 superfamily proteins constitutes a functionally distinct subunit in human hematopoietic progenitors. In: Blood. Volume 99, Number 12, June 2002, pp. 4413-4421, PMID 12036870 .
  10. ↑ Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, Rubinstein E: Selective tetraspan-integrin complexes (CD81 / alpha4beta1, CD151 / alpha3beta1, CD151 / alpha6beta1) under conditions disrupting tetraspan interactions . In: Biochem. J. . 340, No. Pt 1, May 1999, pp. 103-11. doi : 10.1042 / 0264-6021: 3400103 . PMID 10229664 . PMC 1220227 (free full text).
  11. ↑ A. Mazzocca, V. Carloni, S. Sciammetta, C. Cordella, P. Pantaleo, A. Caldini, P. Gentilini, M. Pinzani: Expression of transmembrane 4 superfamily (TM4SF) proteins and their role in hepatic stellate cell motility and wound healing migration. In: Journal of hepatology. Volume 37, Number 3, September 2002, pp. 322-330, PMID 12175627 .
  12. ↑ KL Clark, Z. Zeng, AL Langford, SM Bowen, SC Todd: PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins. In: Journal of Immunology. Volume 167, Number 9, November 2001, pp. 5115-5121, PMID 11673522 .
  13. ^ Levy S, Todd SC, Maecker HT: CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system . In: Annu Rev Immunol. . 16, 1998, pp. 89-109. doi : 10.1146 / annurev.immunol.16.1.89 . PMID 9597125 .
  14. ↑ B. Bartosch, A. Vitelli, C. Granier, C. Goujon, J. Dubuisson, S. Pascale, E. Scarselli, R. Cortese, A. Nicosia, FL Cosset: Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor. In: The Journal of biological chemistry. Volume 278, Number 43, October 2003, pp. 41624-41630, doi : 10.1074 / jbc.M305289200 , PMID 12913001 .
  15. ↑ S. Yalaoui, S. Zougbédé, S. Charrin, O. Silvie, C. Arduise, K. Farhati, C. Boucheix, D. Mazier, E. Rubinstein, P. Froissard: Hepatocyte permissiveness to Plasmodium infection is conveyed by a short and structurally conserved region of the CD81 large extracellular domain. In: PLoS pathogens. Volume 4, number 2, February 2008, p. E1000010, doi : 10.1371 / journal.ppat.1000010 , PMID 18389082 , PMC 2279262 (free full text).
  16. ↑ O. Silvie, E. Rubinstein, JF Franetich, M. Prenant, E. Belnoue, L. Rénia, L. Hannoun, W. Eling, S. Levy, C. Boucheix, D. Mazier: Hepatocyte CD81 is required for Plasmodium falciparum and Plasmodium yoelii sporozoite infectivity. In: Nature medicine. Volume 9, Number 1, January 2003, pp. 93-96, doi : 10.1038 / nm808 , PMID 12483205 .
  17. ↑ LA Fast, D. Lieber, T. Lang, L. Florin: Tetraspanins in infections by human cytomegalo- and papillomaviruses. In: Biochemical Society transactions. Volume 45, Number 2, April 2017, pp. 489-497, doi : 10.1042 / BST20160295 , PMID 28408489 .
  18. ^ Rajesh S, Sridhar P, Tews BA, Fénéant L, Cocquerel L, Ward DG, Berditchevski F, Overduin M: Structural basis of ligand interactions of the large extracellular domain of tetraspanin CD81 . In: J Virol . 86, No. 18, June 2012, pp. 9606-16. doi : 10.1128 / JVI.00559-12 . PMID 22740401 . PMC 3446547 (free full text).
  19. ↑ Holzer M, Ziegler S, Albrecht B, Kronenberger B, Kaul A, Bartenschlager R, Kattner L, Klein CD, Hartmann RW: Identification of terfenadine as an inhibitor of human CD81-receptor HCV-E2 interaction: synthesis and structure optimization . In: Molecules . 13, No. 5, 2008, pp. 1081-110. doi : 10.3390 / molecules13051081 . PMID 18560330 .