B lymphocyte antigen CD19

B-lymphocyte antigen CD19
other names	B-lymphocyte surface antigen B4, differentiation antigen CD19, T-cell surface antigen Leu-12, CD_antigen: CD19
Properties of human protein
Mass / length primary structure	556 amino acids , 61,128 Da
Identifier
External IDs	GeneCards : CD19 ; UniProt : P15391 ;

B-lymphocyte antigen CD19 is a surface protein of the immunoglobulin superfamily . It binds to the cell surface of B cells in the B-cell receptor and decreases the threshold of activation capacity. The overexpression of CD19 in mice and knockout mice shows that CD19 influences the signal threshold of receptors that regulate the selection, activation and differentiation of B lymphocytes . At the molecular level, CD19 is involved in the activation of phosphatidylinositol-4,5-bisphosphate-3-kinases (PI3K) . It is glycosylated and phosphorylated.

CD19 binds to CD81 , CD82 , complement receptor 2 and VAV2 .

Web links

MeSH B lymphocyte antigen CD19

Individual evidence

^ R. Carter, D. Fearon: CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes. In: Science. 256, 1992, p. 105, doi : 10.1126 / science.1373518 .
↑ P. Engel, LJ Zhou, DC Ord, S. Sato, B. Koller, TF Tedder: Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. In: Immunity. Volume 3, Number 1, July 1995, pp. 39-50, PMID 7542548 .
↑ AM Buhl, JC Cambier: Phosphorylation of CD19 Y484 and Y515, and linked activation of phosphatidylinositol 3-kinase, are required for B cell antigen receptor-mediated activation of Bruton's tyrosine kinase. In: Journal of Immunology (Baltimore, Md.: 1950). Vol. 162, Number 8, April 1999, pp. 4438-4446, PMID 10201980 .
↑ ^a ^b Bradbury LE, Kansas GS, Levy S, Evans RL, Tedder TF: The CD19 / CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules . In: Journal of Immunology . 149, No. 9, Nov 1992, pp. 2841-50. PMID 1383329 .
↑ ^a ^b Horváth G, Serru V, Clay D, Billard M, Boucheix C, Rubinstein E: CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82 . In: The Journal of Biological Chemistry . 273, No. 46, Nov 1998, pp. 30537-43. doi : 10.1074 / jbc.273.46.30537 . PMID 9804823 .
↑ ^a ^b Imai T, Kakizaki M, Nishimura M, Yoshie O: Molecular analyzes of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82 . In: Journal of Immunology . 155, No. 3, Aug 1995, pp. 1229-39. PMID 7636191 .
↑ Doody GM, Billadeau DD, Clayton E, Hutchings A, Berland R, McAdam S, Leibson PJ, Turner M: Vav-2 controls NFAT-dependent transcription in B-but not T-lymphocytes . In: The EMBO Journal . 19, No. 22, Nov 2000, pp. 6173-84. doi : 10.1093 / emboj / 19.22.6173 . PMID 11080163 . PMC 305817 (free full text).

[DOI10.1126/science.1373518-1] R. Carter, D. Fearon: CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes. In: Science. 256, 1992, p. 105, doi : 10.1126 / science.1373518 .

[PMID7542548-2] P. Engel, LJ Zhou, DC Ord, S. Sato, B. Koller, TF Tedder: Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. In: Immunity. Volume 3, Number 1, July 1995, pp. 39-50, PMID 7542548 .

[PMID10201980-3] AM Buhl, JC Cambier: Phosphorylation of CD19 Y484 and Y515, and linked activation of phosphatidylinositol 3-kinase, are required for B cell antigen receptor-mediated activation of Bruton's tyrosine kinase. In: Journal of Immunology (Baltimore, Md.: 1950). Vol. 162, Number 8, April 1999, pp. 4438-4446, PMID 10201980 .

[pmid1383329-4] Bradbury LE, Kansas GS, Levy S, Evans RL, Tedder TF: The CD19 / CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules . In: Journal of Immunology . 149, No. 9, Nov 1992, pp. 2841-50. PMID 1383329 .

[pmid9804823-5] Horváth G, Serru V, Clay D, Billard M, Boucheix C, Rubinstein E: CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82 . In: The Journal of Biological Chemistry . 273, No. 46, Nov 1998, pp. 30537-43. doi : 10.1074 / jbc.273.46.30537 . PMID 9804823 .

[pmid7636191-6] Imai T, Kakizaki M, Nishimura M, Yoshie O: Molecular analyzes of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82 . In: Journal of Immunology . 155, No. 3, Aug 1995, pp. 1229-39. PMID 7636191 .

[pmid11080163-7] Doody GM, Billadeau DD, Clayton E, Hutchings A, Berland R, McAdam S, Leibson PJ, Turner M: Vav-2 controls NFAT-dependent transcription in B-but not T-lymphocytes . In: The EMBO Journal . 19, No. 22, Nov 2000, pp. 6173-84. doi : 10.1093 / emboj / 19.22.6173 . PMID 11080163 . PMC 305817 (free full text).