Tspan-27

CD82 antigen
other names	C33 antigen, IA4, Inducible membrane protein R2, Metastasis suppressor Kangai-1, Suppressor of tumorigenicity 6 protein, Tetraspanin-27, Tspan-27
Properties of human protein
Mass / length primary structure	267 amino acids , 29,626 Da
Identifier
External IDs	GeneCards : CD82 ; OMIM : 600623 ; UniProt : P27701 ;
	Orthologue (human)
Entrez	3732
Ensemble	ENSG00000085117
UniProt	P27701
Refseq (mRNA)	NM_001024844.1
Refseq (protein)	NP_001020015.1
PubMed search	3732

Tspan-27 (synonymous CD82 ) is a surface protein from the group of tetraspanins and a tumor suppressor .

properties

Tspan-27 is made by lymphocytes . It is used to sort membrane proteins by structuring areas of the cell membrane. It reduces the metastasis and progression of tumors . Metastasis is inhibited by inhibiting motility , promoting cell polarity and initiating senescence and apoptosis as a reaction to certain extracellular signaling molecules. Tspan-27 regulates the composition of microdomains and the surface area in the cell membrane . It's glycosylated . Tspan-27 binds to CD19 , CD63 and CD234 .

Web links

MeSH Tspan-27

Individual evidence

^ M. Thali: Tetraspanin functions during HIV-1 and influenza virus replication. In: Biochemical Society transactions. Volume 39, number 2, April 2011, pp. 529-531, doi : 10.1042 / BST0390529 , PMID 21428933 , PMC 4067976 (free full text).
↑ YC Tsai, AM Weissman: Dissecting the diverse functions of the metastasis suppressor CD82 / KAI1. In: FEBS letters. Volume 585, Number 20, October 2011, pp. 3166-3173, doi : 10.1016 / j.febslet.2011.08.031 , PMID 21875585 , PMC 3409691 (free full text).
↑ J. Feng, C. Huang, JD Wren, DW Wang, J. Yan, J. Zhang, Y. Sun, X. Han, XA Zhang: Tetraspanin CD82: a suppressor of solid tumors and a modulator of membrane heterogeneity. In: Cancer metastasis reviews. Volume 34, Number 4, December 2015, pp. 619-633, doi : 10.1007 / s10555-015-9585-x , PMID 26335499 .
↑ T. Imai, M. Kakizaki, M. Nishimura, O. Yoshie: Molecular analyzes of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82. In: Journal of Immunology. Volume 155, Number 3, August 1995, pp. 1229-1239, PMID 7636191 .
↑ G. Horváth, V. Serru, D. Clay, M. Billard, C. Boucheix, E. Rubinstein: CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82. In: The Journal of biological chemistry. Volume 273, Number 46, November 1998, pp. 30537-30543, PMID 9804823 .
↑ C. Hammond, LK Denzin, M. Pan, JM Griffith, HJ Geuze, P. Cresswell: The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules. In: Journal of Immunology. Volume 161, Number 7, October 1998, pp. 3282-3291, PMID 9759843 .
↑ Jin Hur, Jae-Il Choi, Hwan Lee, Pniel Nham, Tae-Won Kim, Cheong-Whan Chae, Ji-Yeon Yun, Jin-A. Kang, Jeehoon Kang: CD82 / KAI1 Maintains the Dormancy of Long-Term Hematopoietic Stem Cells through Interaction with DARC-Expressing Macrophages . In: Cell Stem Cell . 18, No. 4, April 7, 2016, ISSN 1875-9777 , pp. 508-521. doi : 10.1016 / j.stem.2016.01.013 . PMID 26996598 .

[1] M. Thali: Tetraspanin functions during HIV-1 and influenza virus replication. In: Biochemical Society transactions. Volume 39, number 2, April 2011, pp. 529-531, doi : 10.1042 / BST0390529 , PMID 21428933 , PMC 4067976 (free full text).

[2] YC Tsai, AM Weissman: Dissecting the diverse functions of the metastasis suppressor CD82 / KAI1. In: FEBS letters. Volume 585, Number 20, October 2011, pp. 3166-3173, doi : 10.1016 / j.febslet.2011.08.031 , PMID 21875585 , PMC 3409691 (free full text).

[3] J. Feng, C. Huang, JD Wren, DW Wang, J. Yan, J. Zhang, Y. Sun, X. Han, XA Zhang: Tetraspanin CD82: a suppressor of solid tumors and a modulator of membrane heterogeneity. In: Cancer metastasis reviews. Volume 34, Number 4, December 2015, pp. 619-633, doi : 10.1007 / s10555-015-9585-x , PMID 26335499 .

[pmid7636191-4] T. Imai, M. Kakizaki, M. Nishimura, O. Yoshie: Molecular analyzes of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82. In: Journal of Immunology. Volume 155, Number 3, August 1995, pp. 1229-1239, PMID 7636191 .

[pmid9804823-5] G. Horváth, V. Serru, D. Clay, M. Billard, C. Boucheix, E. Rubinstein: CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82. In: The Journal of biological chemistry. Volume 273, Number 46, November 1998, pp. 30537-30543, PMID 9804823 .

[pmid9759843-6] C. Hammond, LK Denzin, M. Pan, JM Griffith, HJ Geuze, P. Cresswell: The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules. In: Journal of Immunology. Volume 161, Number 7, October 1998, pp. 3282-3291, PMID 9759843 .

[7] Jin Hur, Jae-Il Choi, Hwan Lee, Pniel Nham, Tae-Won Kim, Cheong-Whan Chae, Ji-Yeon Yun, Jin-A. Kang, Jeehoon Kang: CD82 / KAI1 Maintains the Dormancy of Long-Term Hematopoietic Stem Cells through Interaction with DARC-Expressing Macrophages . In: Cell Stem Cell . 18, No. 4, April 7, 2016, ISSN 1875-9777 , pp. 508-521. doi : 10.1016 / j.stem.2016.01.013 . PMID 26996598 .