Platelet glycoprotein 4
| Platelet glycoprotein 4 | ||
|---|---|---|
| other names |
Fatty acid translocase, FAT, Platelet glycoprotein 4, CD36 |
|
| Properties of human protein | ||
| Mass / length primary structure | 472 amino acids , 53,053 Da | |
| Identifier | ||
| External IDs | ||
| Orthologue (human) | ||
| Entrez | 948 | |
| Ensemble | ENSG00000135218 | |
| UniProt | P16671 | |
| Refseq (mRNA) | NM_000072.3 | |
| Refseq (protein) | NP_000063.2 | |
| PubMed search |
948
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Platelet glycoprotein 4 (synonymous CD36 ) is a surface protein that occurs on blood platelets (thrombocytes) , among other things .
properties
Platelet glycoprotein 4 is a receptor for various substances, including thrombospondin , fibronectin , collagen or amyloid beta as well as oxidized LDL , anionic phospholipids , long-chain fatty acids and diacylated lipopeptides . Platelet glycoprotein 4 can form protein complexes with itself (laterally in the cell membrane ). It is involved in angiogenesis , inflammation , lipid metabolism and fat absorption . It is also a coreceptor of the heterodimer of TLR4 and TLR6 and of inflammatory processes in monocytes and macrophages . Plasmodium falciparum use platelet glycoprotein 4 for cell adhesion from parasitized erythrocytes . It is glycosylated and palmitoylated . It is believed to be involved in the development of arteriosclerosis . CD36 is believed to be involved in the perception of the taste of fats .
Web links
Individual evidence
- ↑ A. Cabrera, D. Neculai, KC Kain: CD36 and malaria: friends or foes? A decade of data provides some answers. In: Trends in parasitology. Volume 30, number 9, September 2014, pp. 436-444, doi : 10.1016 / j.pt.2014.07.006 , PMID 25113859 .
- ↑ YM Park: CD36, a scavenger receptor implicated in atherosclerosis. In: Experimental & molecular medicine. Volume 46, June 2014, p. E99, doi : 10.1038 / emm.2014.38 , PMID 24903227 , PMC 4081553 (free full text).
- ^ AS Khan, B. Murtaza, A. Hichami, NA Khan: A cross-talk between fat and bitter taste modalities. In: Biochemistry. [Electronic publication before printing] June 2018, doi : 10.1016 / j.biochi.2018.06.013 , PMID 29936293 .