Ribophorin
Ribophorin | ||
---|---|---|
Mass / length primary structure | 584 amino acids | |
Secondary to quaternary structure | Single pass membrane protein (ER) | |
Identifier | ||
Gene name (s) | RPN1 , RPN2 | |
External IDs | ||
Enzyme classification | ||
EC, category | 2.4.1.119 , transferase | |
Response type | Transfer of an oligosaccharide chain | |
Substrate | Dolichyl diphosphooligosaccharide + protein L-asparagine | |
Products | Dolichyldiphosphate + glycoprotein (N-Asp.-subst.) | |
Occurrence | ||
Parent taxon | Eukaryotes |
Ribophorin (also Dolichyl-diphosphooligosaccharide-Protein-Glycosyltransferase ) is an enzyme in eukaryotes which, together with other polypeptides, is part of the oligosaccharyltransferase complex (OST) in the membrane of the endoplasmic reticulum (ER), which is responsible for the N - glycosylation of other proteins necessary is. Ribophorin is the enzymatically active subunit.
Ribophorin exists in two isoforms in multicellular animals (ribophorin I and II). For ribophorin I it could be shown that it delivers certain proteins to the active center of the oligosaccharyltransferase and thus enables N-glycosylation.
Web links
- About Ribophorin I . Original publication: Cornelia M Wilson, Quentin Roebuck, Stephen High: Ribophorin I regulates substrate delivery to the oligosaccharyltransferase core. In: Proceedings of the National Academy of Sciences (2008) 105 (28): 9534-9. doi : 10.1073 / pnas.0711846105
- Information on oligosyltransferase in the ER (University of Bonn)
Individual evidence
- ↑ Orthologist at OMA
- ↑ Orthologues of Ribophorin II at OMA
- ^ Wilson CM, Roebuck Q, High S: Ribophorin I regulates substrate delivery to the oligosaccharyl transferase core . In: Proc. Natl. Acad. Sci. USA . 105, No. 28, July 2008, pp. 9534-9. doi : 10.1073 / pnas.0711846105 . PMID 18607003 . PMC 2443820 (free full text).