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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{PBB|geneid=7544}}
{{Infobox_gene}}
'''Zinc finger Y-chromosomal protein''' is a [[protein]] that in humans is encoded by the ''ZFY'' [[gene]].<ref name="pmid2497060">{{cite journal | author = Muller G, Schempp W | title = Mapping the human ZFX locus to Xp21.3 by in situ hybridization | journal = Hum Genet | volume = 82 | issue = 1 | pages = 82–4 | year = 1989 | month = Jun | pmid = 2497060 | pmc = | doi =10.1007/BF00288279 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ZFY zinc finger protein, Y-linked| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7544| accessdate = }}</ref>
'''Zinc finger Y-chromosomal protein''' is a [[protein]] that in humans is encoded by the ''ZFY'' [[gene]] of the [[Y chromosome]].<ref name="pmid2497060">{{cite journal | vauthors = Müller G, Schempp W | title = Mapping the human ZFX locus to Xp21.3 by in situ hybridization | journal = Human Genetics | volume = 82 | issue = 1 | pages = 82–4 | date = April 1989 | pmid = 2497060 | doi = 10.1007/BF00288279 | s2cid = 27908892 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ZFY zinc finger protein, Y-linked| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7544}}</ref>


⚫
This gene encodes a [[zinc finger]]-containing protein that may function as a [[transcription factor]]. This gene was once a candidate gene for the [[testis-determining factor]] (TDF) and was erroneously referred to as TDF.<ref name="entrez" />
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{{PBB_Summary
| section_title =
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| summary_text = This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF.<ref name="entrez" />
}}


Humans express a single ZFY gene with two [[alternative splicing|splice variants]], while mice express two [[sequence homology|paralogous]] copies, Zfy1 and Zfy2.<ref name="Vernet_2016">{{cite journal | vauthors = Vernet N, Mahadevaiah SK, de Rooij DG, Burgoyne PS, Ellis PJ | title = Zfy genes are required for efficient meiotic sex chromosome inactivation (MSCI) in spermatocytes | journal = Human Molecular Genetics | volume = 25 | issue = 24 | pages = 5300–5310 | date = December 2016 | pmid = 27742779 | pmc = 5418838 | doi = 10.1093/hmg/ddw344 }}</ref> During [[spermatogenesis]], wrongful expression of either Zfy1 or Zfy2 results in programmed cell death, [[apoptosis]], at the [[meiosis|mid-pachytene]] checkpoint. In mice, Zfy genes are necessary for meiotic sex chromosome inactivation (MSCI). In Zfy knockout spermatocytes, sex chromosomes are incorrectly silenced. Thus, Zfy performs three functions at the mid-pachytene checkpoint: (1) promote MSCI, (2) monitor MSCI progress, and (3) execute cells, via apoptosis, that fail to undergo MSCI.<ref name="Vernet_2016" />
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==References==

In humans, ZFY is most broadly expresses in the testis and prostate. However, 20 other tissues also express ZFY, such as esophagus, urinary bladder, bone marrow, small intestine, appendix and gall bladder.<ref>{{cite web | title = ZFY Gene |url= https://www.genecards.org/cgi-bin/carddisp.pl?gene=ZFY#expression | work = GeneCards |access-date=2019-04-15}}</ref>

Disorders associated with the ZFY gene include [[campomelic dysplasia]], cystadenofibroma, and [[Frasier syndrome]].<ref>{{Cite web|url=https://www.malacards.org/search/results/ZFY |title =MalaCards: Search Human Diseases - ZFY | work = Mala Cards |access-date=2019-04-15}}</ref>

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== References ==
{{reflist}}
{{reflist}}

==Further reading==<!-- CytogenetGenomeRes101:266. -->
== Further reading ==<!-- CytogenetGenomeRes101:266. -->
{{refbegin | 2}}
{{refbegin | 2}}
* {{cite journal | vauthors = Merchant-Larios H, Moreno-Mendoza N | title = Onset of sex differentiation: dialog between genes and cells | journal = Archives of Medical Research | volume = 32 | issue = 6 | pages = 553–8 | year = 2002 | pmid = 11750730 | doi = 10.1016/S0188-4409(01)00317-4 }}
{{PBB_Further_reading
* {{cite journal | vauthors = Kochoyan M, Havel TF, Nguyen DT, Dahl CE, Keutmann HT, Weiss MA | title = Alternating zinc fingers in the human male associated protein ZFY: 2D NMR structure of an even finger and implications for "jumping-linker" DNA recognition | journal = Biochemistry | volume = 30 | issue = 14 | pages = 3371–86 | date = April 1991 | pmid = 1849423 | doi = 10.1021/bi00228a004 | s2cid = 24544613 }}
| citations =
*{{cite journal | author=Merchant-Larios H, Moreno-Mendoza N |title=Onset of sex differentiation: dialog between genes and cells |journal=Arch. Med. Res. |volume=32 |issue= 6 |pages= 553–8 |year= 2002 |pmid= 11750730 |doi=10.1016/S0188-4409(01)00317-4 }}
* {{cite journal | vauthors = Kochoyan M, Keutmann HT, Weiss MA | title = Alternating zinc fingers in the human male associated protein ZFY: refinement of the NMR structure of an even finger by selective deuterium labeling and implications for DNA recognition | journal = Biochemistry | volume = 30 | issue = 29 | pages = 7063–72 | date = July 1991 | pmid = 1854720 | doi = 10.1021/bi00243a005 }}
*{{cite journal | author=Kochoyan M, Havel TF, Nguyen DT, ''et al.'' |title=Alternating zinc fingers in the human male associated protein ZFY: 2D NMR structure of an even finger and implications for "jumping-linker" DNA recognition |journal=Biochemistry |volume=30 |issue= 14 |pages= 3371–86 |year= 1991 |pmid= 1849423 |doi=10.1021/bi00228a004 }}
* {{cite journal | vauthors = North M, Sargent C, O'Brien J, Taylor K, Wolfe J, Affara NA, Ferguson-Smith MA | title = Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY | journal = Nucleic Acids Research | volume = 19 | issue = 10 | pages = 2579–86 | date = May 1991 | pmid = 2041734 | pmc = 328173 | doi = 10.1093/nar/19.10.2579 }}
*{{cite journal | author=Kochoyan M, Keutmann HT, Weiss MA |title=Alternating zinc fingers in the human male associated protein ZFY: refinement of the NMR structure of an even finger by selective deuterium labeling and implications for DNA recognition |journal=Biochemistry |volume=30 |issue= 29 |pages= 7063–72 |year= 1991 |pmid= 1854720 |doi=10.1021/bi00243a005 }}
* {{cite journal | vauthors = Palmer MS, Berta P, Sinclair AH, Pym B, Goodfellow PN | title = Comparison of human ZFY and ZFX transcripts | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 87 | issue = 5 | pages = 1681–5 | date = March 1990 | pmid = 2308929 | pmc = 53546 | doi = 10.1073/pnas.87.5.1681 | bibcode = 1990PNAS...87.1681P | doi-access = free }}
*{{cite journal | author=North M, Sargent C, O'Brien J, ''et al.'' |title=Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY |journal=Nucleic Acids Res. |volume=19 |issue= 10 |pages= 2579–86 |year= 1991 |pmid= 2041734 |doi=10.1093/nar/19.10.2579 | pmc=328173 }}
* {{cite journal | vauthors = Affara NA, Chambers D, O'Brien J, Habeebu SS, Kalaitsidaki M, Bishop CE, Ferguson-Smith MA | title = Evidence for distinguishable transcripts of the putative testis determining gene (ZFY) and mapping of homologous cDNA sequences to chromosomes X,Y and 9 | journal = Nucleic Acids Research | volume = 17 | issue = 8 | pages = 2987–99 | date = April 1989 | pmid = 2498838 | pmc = 317707 | doi = 10.1093/nar/17.8.2987 }}
*{{cite journal | author=Palmer MS, Berta P, Sinclair AH, ''et al.'' |title=Comparison of human ZFY and ZFX transcripts |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 5 |pages= 1681–5 |year= 1990 |pmid= 2308929 |doi=10.1073/pnas.87.5.1681 | pmc=53546 }}
* {{cite journal | vauthors = Lau YF, Chan KM | title = The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues | journal = American Journal of Human Genetics | volume = 45 | issue = 6 | pages = 942–52 | date = December 1989 | pmid = 2511751 | pmc = 1683462 }}
*{{cite journal | author=Affara NA, Chambers D, O'Brien J, ''et al.'' |title=Evidence for distinguishable transcripts of the putative testis determining gene (ZFY) and mapping of homologous cDNA sequences to chromosomes X,Y and 9 |journal=Nucleic Acids Res. |volume=17 |issue= 8 |pages= 2987–99 |year= 1989 |pmid= 2498838 |doi=10.1093/nar/17.8.2987 | pmc=317707 }}
* {{cite journal | vauthors = Page DC, Mosher R, Simpson EM, Fisher EM, Mardon G, Pollack J, McGillivray B, de la Chapelle A, Brown LG | title = The sex-determining region of the human Y chromosome encodes a finger protein | journal = Cell | volume = 51 | issue = 6 | pages = 1091–104 | date = December 1987 | pmid = 3690661 | doi = 10.1016/0092-8674(87)90595-2 | s2cid = 7454260 }}
*{{cite journal | author=Lau YF, Chan KM |title=The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues |journal=Am. J. Hum. Genet. |volume=45 |issue= 6 |pages= 942–52 |year= 1990 |pmid= 2511751 |doi= | pmc=1683462 }}
* {{cite journal | vauthors = Tricoli JV, Bracken RB | title = ZFY gene expression and retention in human prostate adenocarcinoma | journal = Genes, Chromosomes & Cancer | volume = 6 | issue = 2 | pages = 65–72 | date = February 1993 | pmid = 7680890 | doi = 10.1002/gcc.2870060202 | s2cid = 7796123 }}
*{{cite journal | author=Page DC, Mosher R, Simpson EM, ''et al.'' |title=The sex-determining region of the human Y chromosome encodes a finger protein |journal=Cell |volume=51 |issue= 6 |pages= 1091–104 |year= 1988 |pmid= 3690661 |doi=10.1016/0092-8674(87)90595-2 }}
* {{cite journal | vauthors = Erlandsson R, Wilson JF, Pääbo S | title = Sex chromosomal transposable element accumulation and male-driven substitutional evolution in humans | journal = Molecular Biology and Evolution | volume = 17 | issue = 5 | pages = 804–12 | date = May 2000 | pmid = 10779541 | doi = 10.1093/oxfordjournals.molbev.a026359 | doi-access = free }}
*{{cite journal | author=Tricoli JV, Bracken RB |title=ZFY gene expression and retention in human prostate adenocarcinoma |journal=Genes Chromosomes Cancer |volume=6 |issue= 2 |pages= 65–72 |year= 1993 |pmid= 7680890 |doi=10.1002/gcc.2870060202 }}
* {{cite journal | vauthors = Mittwoch U | title = Three thousand years of questioning sex determination | journal = Cytogenetics and Cell Genetics | volume = 91 | issue = 1–4 | pages = 186–91 | year = 2001 | pmid = 11173854 | doi = 10.1159/000056842 | s2cid = 20017749 }}
* {{cite journal | vauthors = Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, Cordum HS, Hillier L, Brown LG, Repping S, Pyntikova T, Ali J, Bieri T, Chinwalla A, Delehaunty A, Delehaunty K, Du H, Fewell G, Fulton L, Fulton R, Graves T, Hou SF, Latrielle P, Leonard S, Mardis E, Maupin R, McPherson J, Miner T, Nash W, Nguyen C, Ozersky P, Pepin K, Rock S, Rohlfing T, Scott K, Schultz B, Strong C, Tin-Wollam A, Yang SP, Waterston RH, Wilson RK, Rozen S, Page DC | title = The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes | journal = Nature | volume = 423 | issue = 6942 | pages = 825–37 | date = June 2003 | pmid = 12815422 | doi = 10.1038/nature01722 | bibcode = 2003Natur.423..825S | doi-access = free }}
*{{cite journal | author=Erlandsson R, Wilson JF, Pääbo S |title=Sex chromosomal transposable element accumulation and male-driven substitutional evolution in humans |journal=Mol. Biol. Evol. |volume=17 |issue= 5 |pages= 804–12 |year= 2000 |pmid= 10779541 |doi= }}
*{{cite journal | author=Mittwoch U |title=Three thousand years of questioning sex determination |journal=Cytogenet. Cell Genet. |volume=91 |issue= 1–4 |pages= 186–91 |year= 2001 |pmid= 11173854 |doi=10.1159/000056842 }}
* {{cite journal | vauthors = Agate RJ, Choe M, Arnold AP | title = Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches | journal = Molecular Biology and Evolution | volume = 21 | issue = 2 | pages = 384–96 | date = February 2004 | pmid = 14660691 | doi = 10.1093/molbev/msh027 | doi-access = free }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, ''et al.'' |title=The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes |journal=Nature |volume=423 |issue= 6942 |pages= 825–37 |year= 2003 |pmid= 12815422 |doi= 10.1038/nature01722 }}
*{{cite journal | author=Agate RJ, Choe M, Arnold AP |title=Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches |journal=Mol. Biol. Evol. |volume=21 |issue= 2 |pages= 384–96 |year= 2004 |pmid= 14660691 |doi= 10.1093/molbev/msh027 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=7544}}
{{PDB Gallery|geneid=7544}}


[[Category:Genes on human chromosome Y]]
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{{protein-stub}}
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Latest revision as of 13:40, 18 December 2023

ZFY
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesZFY, ZNF911, zinc finger protein, Y-linked, zinc finger protein Y-linked
External IDsOMIM: 490000 HomoloGene: 88465 GeneCards: ZFY
Orthologs
SpeciesHumanMouse
Entrez

7544

n/a

Ensembl

ENSG00000067646

n/a

UniProt

P08048

n/a

RefSeq (mRNA)

NM_001145275
NM_001145276
NM_003411

n/a

RefSeq (protein)

n/a

Location (UCSC)Chr Y: 2.94 – 2.98 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Zinc finger Y-chromosomal protein is a protein that in humans is encoded by the ZFY gene of the Y chromosome.[3][4]

This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF.[4]

Humans express a single ZFY gene with two splice variants, while mice express two paralogous copies, Zfy1 and Zfy2.[5] During spermatogenesis, wrongful expression of either Zfy1 or Zfy2 results in programmed cell death, apoptosis, at the mid-pachytene checkpoint. In mice, Zfy genes are necessary for meiotic sex chromosome inactivation (MSCI). In Zfy knockout spermatocytes, sex chromosomes are incorrectly silenced. Thus, Zfy performs three functions at the mid-pachytene checkpoint: (1) promote MSCI, (2) monitor MSCI progress, and (3) execute cells, via apoptosis, that fail to undergo MSCI.[5]

In humans, ZFY is most broadly expresses in the testis and prostate. However, 20 other tissues also express ZFY, such as esophagus, urinary bladder, bone marrow, small intestine, appendix and gall bladder.[6]

Disorders associated with the ZFY gene include campomelic dysplasia, cystadenofibroma, and Frasier syndrome.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000067646 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Müller G, Schempp W (April 1989). "Mapping the human ZFX locus to Xp21.3 by in situ hybridization". Human Genetics. 82 (1): 82–4. doi:10.1007/BF00288279. PMID 2497060. S2CID 27908892.
  4. ^ a b "Entrez Gene: ZFY zinc finger protein, Y-linked".
  5. ^ a b Vernet N, Mahadevaiah SK, de Rooij DG, Burgoyne PS, Ellis PJ (December 2016). "Zfy genes are required for efficient meiotic sex chromosome inactivation (MSCI) in spermatocytes". Human Molecular Genetics. 25 (24): 5300–5310. doi:10.1093/hmg/ddw344. PMC 5418838. PMID 27742779.
  6. ^ "ZFY Gene". GeneCards. Retrieved 2019-04-15.
  7. ^ "MalaCards: Search Human Diseases - ZFY". Mala Cards. Retrieved 2019-04-15.

Further reading[edit]

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