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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{notability|date=June 2017}}
{{Infobox_gene}}
'''Zinc finger Y-chromosomal protein''' is a [[protein]] that in humans is encoded by the ''ZFY'' [[gene]] of the [[Y chromosome]].<ref name="pmid2497060">{{cite journal | vauthors = MullerMüller G, Schempp W | title = Mapping the human ZFX locus to Xp21.3 by in situ hybridization | journal = HumHuman GenetGenetics | volume = 82 | issue = 1 | pages = 82–4 | date =Jun April 1989 | pmid = 2497060 | pmc = | doi = 10.1007/BF00288279 | s2cid = 27908892 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ZFY zinc finger protein, Y-linked| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7544| accessdate = }}</ref>
 
| summary_text = This gene encodes a [[zinc finger]]-containing protein that may function as a [[transcription factor]]. This gene was once a candidate gene for the [[testis-determining factor]] (TDF) and was erroneously referred to as TDF.<ref name="entrez" />▼
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{{PBB_Summary
| section_title =
▲| summary_text = This gene encodes a [[zinc finger]]-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF.<ref name="entrez" />
}}
 
Humans express a single ZFY gene with two [[alternative splicing|splice variants]], while mice express two [[sequence homology|paralogous]] copies, Zfy1 and Zfy2.<ref name="Vernet_2016">{{cite journal | vauthors = Vernet N, Mahadevaiah SK, de Rooij DG, Burgoyne PS, Ellis PJ | title = Zfy genes are required for efficient meiotic sex chromosome inactivation (MSCI) in spermatocytes | journal = Human Molecular Genetics | volume = 25 | issue = 24 | pages = 5300–5310 | date = December 2016 | pmid = 27742779 | pmc = 5418838 | doi = 10.1093/hmg/ddw344 }}</ref> During [[spermatogenesis]], wrongful expression of either Zfy1 or Zfy2 results in programmed cell death, [[apoptosis]], at the [[meiosis|mid-pachytene]] checkpoint. In mice, Zfy genes are necessary for meiotic sex chromosome inactivation (MSCI). In Zfy knockout spermatocytes, sex chromosomes are incorrectly silenced. Thus, Zfy performs three functions at the mid-pachytene checkpoint: (1) promote MSCI, (2) monitor MSCI progress, and (3) execute cells, via apoptosis, that fail to undergo MSCI.<ref name="Vernet_2016" />
==References==▼
 
In humans, ZFY is most broadly expresses in the testis and prostate. However, 20 other tissues also express ZFY, such as esophagus, urinary bladder, bone marrow, small intestine, appendix and gall bladder.<ref>{{cite web | title = ZFY Gene |url= https://www.genecards.org/cgi-bin/carddisp.pl?gene=ZFY#expression | work = GeneCards |access-date=2019-04-15}}</ref>
 
Disorders associated with the ZFY gene include [[campomelic dysplasia]], cystadenofibroma, and [[Frasier syndrome]].<ref>{{Cite web|url=https://www.malacards.org/search/results/ZFY |title =MalaCards: Search Human Diseases - ZFY | work = Mala Cards |access-date=2019-04-15}}</ref>
 
▲== References ==
{{reflist}}
 
== Further reading ==<!-- CytogenetGenomeRes101:266. -->
{{refbegin | 2}}
* {{cite journal | vauthors = Merchant-Larios H, Moreno-Mendoza N | title = Onset of sex differentiation: dialog between genes and cells | journal = Archives of Medical Research | volume = 32 | issue = 6 | pages = 553–8 | year = 2002 | pmid = 11750730 | doi = 10.1016/S0188-4409(01)00317-4 }}
{{PBB_Further_reading
* {{cite journal | vauthors = Kochoyan M, Havel TF, Nguyen DT, Dahl CE, Keutmann HT, Weiss MA | title = Alternating zinc fingers in the human male associated protein ZFY: 2D NMR structure of an even finger and implications for "jumping-linker" DNA recognition | journal = Biochemistry | volume = 30 | issue = 14 | pages = 3371–86 | date = April 1991 | pmid = 1849423 | doi = 10.1021/bi00228a004 | s2cid = 24544613 }}
| citations =
* {{cite journal | vauthors =Merchant-Larios HKochoyan M, Moreno-MendozaKeutmann NHT, Weiss MA | title =Onset ofAlternating sexzinc differentiationfingers in the human male associated protein ZFY: dialogrefinement betweenof genesthe NMR structure of an even finger by selective deuterium labeling and cellsimplications for DNA recognition | journal =Arch. Med.Biochemistry Res.| |volume =32 30 | issue = 629 | pages = 553–87063–72 |year date = 2002July 1991 | pmid = 117507301854720 | doi = 10.10161021/S0188-4409(01)00317-4 bi00243a005 }}
* {{cite journal | vauthors =Kochoyan North M, HavelSargent TFC, NguyenO'Brien DTJ, etalTaylor |title=AlternatingK, zincWolfe fingersJ, inAffara theNA, humanFerguson-Smith maleMA associated| proteintitle ZFY:= 2DComparison NMRof structureZFY ofand anZFX evengene fingerstructure and implicationsanalysis forof "jumping-linker"alternative DNA3' recognitionuntranslated regions of ZFY | journal =Biochemistry Nucleic Acids Research | volume =30 19 | issue = 1410 | pages = 3371–862579–86 |year date = May 1991 | pmid = 18494232041734 | pmc = 328173 | doi = 10.10211093/bi00228a004 nar/19.10.2579 }}
* {{cite journal | vauthors =Kochoyan MPalmer MS, KeutmannBerta HTP, WeissSinclair MAAH, |title=AlternatingPym zincB, fingersGoodfellow inPN the| humantitle male= associatedComparison proteinof human ZFY: refinementand ofZFX thetranscripts NMR| structurejournal of= anProceedings evenof fingerthe byNational selectiveAcademy deuteriumof labelingSciences andof implicationsthe forUnited DNAStates recognitionof |journal=BiochemistryAmerica | volume =30 87 | issue = 295 | pages = 7063–721681–5 |year date = 1991March 1990 | pmid = 18547202308929 | pmc = 53546 | doi = 10.10211073/bi00243a005pnas.87.5.1681 | bibcode = 1990PNAS...87.1681P | doi-access = free }}
* {{cite journal | vauthors =North MAffara NA, SargentChambers CD, O'Brien J, etalHabeebu SS, Kalaitsidaki M, Bishop CE, Ferguson-Smith MA | title =Comparison Evidence for distinguishable transcripts of ZFYthe andputative ZFXtestis determining gene structure(ZFY) and analysismapping of alternativehomologous 3'cDNA untranslatedsequences regionsto ofchromosomes ZFYX,Y and 9 | journal = Nucleic Acids Res.Research | volume =19 17 | issue = 108 | pages = 2579–862987–99 |year date = 1991April 1989 | pmid = 20417342498838 | pmc = 317707 | doi = 10.1093/nar/1917.108.2579 | pmc=328173 2987 }}
* {{cite journal | vauthors=Palmer MS,= BertaLau PYF, SinclairChan AH,KM etal| |title =Comparison ofThe humanputative ZFYtestis-determining factor and ZFXrelated genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues | journal =Proc. Natl.American Acad.Journal Sci.of U.S.A.Human Genetics | volume =87 45 | issue = 56 | pages = 1681–5942–52 |year= 1990date |pmid= 2308929December 1989 |doi pmid =10.1073/pnas.87.5.1681 2511751 | pmc =53546 1683462 }}
* {{cite journal | vauthors =Affara NAPage DC, ChambersMosher DR, O'BrienSimpson EM, Fisher EM, Mardon G, Pollack J, etalMcGillivray |title=EvidenceB, forde distinguishablela transcriptsChapelle ofA, theBrown putativeLG testis| determiningtitle gene= (ZFY)The andsex-determining mappingregion of homologousthe cDNAhuman sequencesY tochromosome chromosomesencodes X,Ya andfinger 9protein | journal =Nucleic Acids Res.Cell | volume =17 51 | issue = 86 | pages = 2987–991091–104 |year date = 1989December 1987 | pmid = 24988383690661 | doi = 10.10931016/nar/17.8.2987 0092-8674(87)90595-2 | pmcs2cid =317707 7454260 }}
* {{cite journal | vauthors =Lau YFTricoli JV, ChanBracken KMRB | title =The putativeZFY testis-determininggene factorexpression and relatedretention genesin arehuman expressedprostate asadenocarcinoma discrete-sized| transcriptsjournal in= adultGenes, gonadal andChromosomes somatic& tissuesCancer |journal=Am. J.volume Hum.= Genet.6 |volume=45 |issue = 62 | pages = 942–5265–72 |year date = 1990February 1993 | pmid = 25117517680890 | doi = 10.1002/gcc.2870060202 | pmcs2cid =1683462 7796123 }}
* {{cite journal | vauthors =Page DC, MosherErlandsson R, SimpsonWilson EMJF, etalPääbo S | title =The sex-determiningSex regionchromosomal oftransposable theelement humanaccumulation Yand chromosomemale-driven encodessubstitutional aevolution fingerin proteinhumans | journal =Cell Molecular Biology and Evolution | volume =51 17 | issue = 65 | pages = 1091–104804–12 |year date = 1988May 2000 | pmid = 369066110779541 | doi = 10.10161093/0092oxfordjournals.molbev.a026359 | doi-8674(87)90595-2access = free }}
* {{cite journal | vauthors =Tricoli JV,Mittwoch Bracken RBU | title =ZFY geneThree expressionthousand andyears retentionof inquestioning humansex prostate adenocarcinomadetermination | journal =Genes ChromosomesCytogenetics Cancerand Cell Genetics | volume =6 91 | issue = 21–4 | pages = 65–72186–91 | year = 19932001 | pmid = 768089011173854 | doi = 10.10021159/gcc.2870060202000056842 | s2cid = 20017749 }}
* {{cite journal | vauthors = Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, Cordum HS, Hillier L, Brown LG, Repping S, Pyntikova T, Ali J, Bieri T, Chinwalla A, Delehaunty A, Delehaunty K, Du H, Fewell G, Fulton L, Fulton R, Graves T, Hou SF, Latrielle P, Leonard S, Mardis E, Maupin R, McPherson J, Miner T, Nash W, Nguyen C, Ozersky P, Pepin K, Rock S, Rohlfing T, Scott K, Schultz B, Strong C, Tin-Wollam A, Yang SP, Waterston RH, Wilson RK, Rozen S, Page DC | title = The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes | journal = Nature | volume = 423 | issue = 6942 | pages = 825–37 | date = June 2003 | pmid = 12815422 | doi = 10.1038/nature01722 | bibcode = 2003Natur.423..825S | doi-access = free }}
*{{cite journal | vauthors=Erlandsson R, Wilson JF, Pääbo S |title=Sex chromosomal transposable element accumulation and male-driven substitutional evolution in humans |journal=Mol. Biol. Evol. |volume=17 |issue= 5 |pages= 804–12 |year= 2000 |pmid= 10779541 |doi= 10.1093/oxfordjournals.molbev.a026359}}
* {{cite journal | authorvauthors =Mittwoch UAgate RJ, Choe M, Arnold AP | title =Three thousandSex yearsdifferences in structure and expression of questioningthe sex determinationchromosome genes CHD1Z and CHD1W in zebra finches | journal =Cytogenet. CellMolecular Genet.Biology and Evolution | volume =91 21 | issue = 1–42 | pages = 186–91384–96 |year date = 2001February 2004 | pmid = 1117385414660691 | doi = 10.11591093/000056842molbev/msh027 | doi-access = free }}
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal |vauthors=Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, etal |title=The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes |journal=Nature |volume=423 |issue= 6942 |pages= 825–37 |year= 2003 |pmid= 12815422 |doi= 10.1038/nature01722 }}
*{{cite journal | vauthors=Agate RJ, Choe M, Arnold AP |title=Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches |journal=Mol. Biol. Evol. |volume=21 |issue= 2 |pages= 384–96 |year= 2004 |pmid= 14660691 |doi= 10.1093/molbev/msh027 }}
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
}}
{{refend}}
{{PDB Gallery|geneid=7544}}
 
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[[Category:Genes on human chromosome Y]]
 
 
{{protein-stub}}

Revision as of 13:40, 18 December 2023

ZFY
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesZFY, ZNF911, zinc finger protein, Y-linked, zinc finger protein Y-linked
External IDsOMIM: 490000 HomoloGene: 88465 GeneCards: ZFY
Orthologs
SpeciesHumanMouse
Entrez

7544

n/a

Ensembl

ENSG00000067646

n/a

UniProt

P08048

n/a

RefSeq (mRNA)

NM_001145275
NM_001145276
NM_003411

n/a

RefSeq (protein)

n/a

Location (UCSC)Chr Y: 2.94 – 2.98 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Zinc finger Y-chromosomal protein is a protein that in humans is encoded by the ZFY gene of the Y chromosome.[3][4]

This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF.[4]

Humans express a single ZFY gene with two splice variants, while mice express two paralogous copies, Zfy1 and Zfy2.[5] During spermatogenesis, wrongful expression of either Zfy1 or Zfy2 results in programmed cell death, apoptosis, at the mid-pachytene checkpoint. In mice, Zfy genes are necessary for meiotic sex chromosome inactivation (MSCI). In Zfy knockout spermatocytes, sex chromosomes are incorrectly silenced. Thus, Zfy performs three functions at the mid-pachytene checkpoint: (1) promote MSCI, (2) monitor MSCI progress, and (3) execute cells, via apoptosis, that fail to undergo MSCI.[5]

In humans, ZFY is most broadly expresses in the testis and prostate. However, 20 other tissues also express ZFY, such as esophagus, urinary bladder, bone marrow, small intestine, appendix and gall bladder.[6]

Disorders associated with the ZFY gene include campomelic dysplasia, cystadenofibroma, and Frasier syndrome.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000067646 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Müller G, Schempp W (April 1989). "Mapping the human ZFX locus to Xp21.3 by in situ hybridization". Human Genetics. 82 (1): 82–4. doi:10.1007/BF00288279. PMID 2497060. S2CID 27908892.
  4. ^ a b "Entrez Gene: ZFY zinc finger protein, Y-linked".
  5. ^ a b Vernet N, Mahadevaiah SK, de Rooij DG, Burgoyne PS, Ellis PJ (December 2016). "Zfy genes are required for efficient meiotic sex chromosome inactivation (MSCI) in spermatocytes". Human Molecular Genetics. 25 (24): 5300–5310. doi:10.1093/hmg/ddw344. PMC 5418838. PMID 27742779.
  6. ^ "ZFY Gene". GeneCards. Retrieved 2019-04-15.
  7. ^ "MalaCards: Search Human Diseases - ZFY". Mala Cards. Retrieved 2019-04-15.

Further reading

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