Agrypnia excitata

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Classification according to ICD-10
G47 sleep disorders
G47.0 Difficulty falling asleep and staying asleep
F10.4 Mental and behavioral disorders due to alcohol
ICD-10 online (WHO version 2019)

Agrypnia (Greek for insomnia ) excitata (Latin for excited) is a term from sleep research . It is used as a generic term for diseases in which the affected patients do not experience stages 3 and 4 of non-REM sleep . In particular, these include fatal familial insomnia , Morvan syndrome and delirium tremens . Typically, abnormal REM sleep occurs in all cases .

The reasons for the lack of levels 3 and 4 of non-REM sleep are different:

  • In the case of fatal familial insomnia , an imbalance between activation and deactivation of structures in the limbic system is caused by atrophy of the mediodorsal and anteroventral thalamic nuclei .
  • In Morvan syndrome and delirium tremens , a functional imbalance in the control loops between the thalamus and the limbic system is blamed. The cause here is assumed to be the direct effect of alcohol with long-term consumption or the formation of antibodies.
Normal EEG in stages of NREM sleep affected by Agrypnia Excitata . The delta waves outlined in red then do not occur.

In medical theory, the concept of Agrypnia Excitata ultimately also leads to the fact that not 2 but 3 independent sleep phases can be assumed.

Individual evidence

  1. ↑ a b E. Lugaresi: Agrypnia excitata: clinical features and pathophysiological implications . In: Sleep Medicine Reviews . 5/4, pp. 313–322 here online
  2. ↑ a b P. Montagna: Agrypnia Excitata: a generalized overactivity syndrome and a useful concept in the neurophysiopathology of sleep. In: Clinical Neurophysiology . 113/4, p. 552. online here