Andreas Zirlik

Andreas Zirlik (born January 22, 1974 in Schweinfurt ) is a German doctor. His scientific focus is on research into inflammatory and immunological mechanisms at the interface between atherosclerosis, myocardial infarction and metabolic syndrome. His clinical interest is in interventional cardiology and, in the structural heart area, in particular interventional interventions on the mitral valve.

Live and act

After graduating from high school and successfully passing the Bavarian gifted test, he studied medicine at the University of Leipzig from 1993 to 1999. He was awarded the Wolfgang Natonek Prize by the University of Leipzig for special commitment to the interests of students and outstanding academic achievements. He then began his training in internal medicine and cardiology at the Freiburg University Clinic under the guidance of Christoph Bode. From 2003 to 2005 he completed a post-doctoral degree funded by the German Research Foundation (DFG) at the Brighams Women's Hospital at Harvard Medical School in Boston, USA with the cardiologist Peter Libby . Here he developed his passion for immunological mechanisms in vascular diseases and then founded the Atherogenesis Research Group Freiburg after his return to Freiburg.

After obtaining his specialist medical degree, he was promoted to senior physician in 2009 and finally to deputy medical director at the Clinic for Cardiology at the University Heart Center Freiburg in 2013. In October 2018 he was finally appointed professor for internal medicine and cardiology at the Medical University of Graz and has since headed the Clinical Department for Cardiology at the University Heart Center Graz. Andreas Zirlik is the acting President of the German Society for Atherosclerosis Research, Chairman of the Heart and Diabetes Working Group of the German Society for Cardiology and ex officio member of the Board of the Austrian Society for Cardiology.

Awards and grants

1993–1999: Merit scholarship from the Bavarian Free State after successfully completing the Bavarian gifted test
10/1998: Award of the "Wolfgang Natonek Prize" ⁽²⁾ for excellent study results and special commitment to student interests by the association of sponsors and friends of the University of Leipzig eV
07/2003 - 06/2004: Research grant from the German Research Foundation: The role of the CD40 receptor deficiency in atheroma-associated endothelial cells, smooth muscle cells and monocytes / macrophages with special consideration of cell-specific aspects of signal transduction ", DFG-ZI-743 / 1-1
09/2005 - 07/2006: Return grant from the Medical Faculty of the University of Freiburg
12/2007: MSD scholarship for arteriosclerosis / hypertension 2007
2018: Albert Fraenkel Prize of the German Society for Cardiology (DGK)

Literature (excerpt) (1)

Purinergic receptor Y2 (P2Y2) - dependent VCAM-1 expression promotes immune cell infiltration in metabolic syndrome
Risk factors and outcome of postoperative delirium after transcatheter aortic valve replacement
Sex-Specific Differences in Outcome of Transcatheter or Surgical Aortic Valve Replacement
Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass Cytometry
A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense
Coronary magnetic resonance imaging after routine implantation of bioresorbable vascular scaffolds allows non-invasive evaluation of vascular patency
Inflammatory Pathways Regulated by Tumor Necrosis Receptor-Associated Factor 1 Protect From Metabolic Consequences in Diet-Induced Obesity
Novel Reversible Model of Atherosclerosis and Regression Using Oligonucleotide Regulation of the LDL Receptor
Gene expression analysis to identify mechanisms underlying heart failure susceptibility in mice and humans
Dual targeting improves capture of ultrasound microbubbles towards activated platelets but yields no additional benefit for imaging of arterial thrombosis

Patents

08/17/2011 European patent application "Selective Targeting of the CD40L / Mac-1 interaction by small peptide inhibitors and its use for the treatment of inflammation and atherogenesis" (EP 2444101 A1) ⁽²⁾
06/21/2016 European patent application "Antibodies for the selective inhibition of inflammation and pharmaceutical compositions containing such antibodies" (EP 16175382.7) ⁽³⁾

Web links

personal data
SURNAME	Zirlik, Andreas
BRIEF DESCRIPTION	German medic
DATE OF BIRTH	22nd January 1974
PLACE OF BIRTH	Schweinfurt