Antibiotic-associated hemorrhagic colitis
| Classification according to ICD-10 | |
|---|---|
| A04.8 | Other specified bacterial intestinal infections |
| ICD-10 online (WHO version 2019) | |
The antibiotic-associated hemorrhagic colitis is a special form of inflammatory colon disease caused by treatment with antibiotics is triggered. It must be differentiated from the more common pseudomembranous colitis caused by Clostridioides difficile .
etiology
The disease also typically occurs in young, otherwise relatively healthy patients after - often brief - therapy with penicillins . An overgrowth of the normal intestinal flora with a toxin-producing strain of Klebsiella oxytoca was identified as the trigger . These bacteria can be found in around 2% of the healthy population with no symptoms.
Clinical appearance
The patients suffer from cramping abdominal pain and bloody diarrhea occurs . The colonoscopy reveals edematous swelling and bloody changes in the lining of the colon.
therapy
As a therapy, discontinuation of the triggering antibiotic is usually indicated, after which the symptoms improve in a few days. In severe cases, quinolone antibiotics have also been used successfully.
Individual evidence
- ↑ H. Moulis, RJ Vender: Antibiotic-associated hemorrhagic colitis. In: Journal of clinical gastroenterology. Volume 18, Number 3, April 1994, pp. 227-231, PMID 8034921 (review).
- ↑ Christoph Högenauer, Cord Langner u. a .: Klebsiella oxytoca as a Causative Organism of Antibiotic-Associated Hemorrhagic Colitis. In: New England Journal of Medicine. 355, 2006, pp. 2418-2426, doi : 10.1056 / NEJMoa054765 .
- ↑ Antibiotic Associated Hemorrhagic Colitis: The Need to Distinguish from Clostridium difficile Colitis. L. Dharmarajan et al., Practical Gastroenterology, January 2009.
