Bicuspid

The picture shows the three crescent-shaped pockets on the aortic valve and the pulmonary valve

Bicuspidation is a malformation of the aortic or pulmonary valve . Both heart valves usually consist of three crescent-shaped pockets (semilunar valves), but in this case only two.

Bicuspidity is the most common anatomical variant of the heart ( incidence 1–2%) and occurs more frequently together with coarctation of the aorta . A genetic defect ( NOTCH1 ) is considered to be the cause .

The malformation can be identified by echocardiography or MRI . The extent to which there is a specific disease value is controversial; an influence on life expectancy could not be proven.

Classification according to ICD-10
Q22.3	Other congenital malformations of the pulmonary valve
Q23.1	Congenital aortic valve insufficiency (bicuspid aortic valve)
ICD-10 online (WHO version 2019)

Individual evidence

↑ Sieglinde Bogensberger include: Hexal Taschenlexikon medicine. = Pocket dictionary medicine. 3rd, revised and expanded edition. Elsevier, Urban & Fischer, Munich et al. 2004, ISBN 3-437-15011-1 , p. 82 .
↑ Bi | kus | pi | da | li | ity. In: Roche Lexicon Medicine. 5th edition. Urban & Fischer, Munich et al. 2003, ISBN 3-437-15170-3 .
↑ ^a ^b Vidu Garg, Alecia N. Muth, Joshua F. Ransom, Marie K. Schluterman, Robert Barnes, Isabelle N. King, Paul D. Grossfeld, Deepak Srivastava: Mutations in NOTCH1 cause aortic valve disease. In: Nature . Vol. 437, No. 7056, 2005, pp. 270-274, PMID 16025100 , doi : 10.1038 / nature03940 .
↑ Ali Sarigül, Yurdakul Yurdakul, Selim Isbir, Sükrü Mercan, Alpay Celiker: Bicuspid aortic valve and coarctation of aorta. In: The Turkish Journal of Pediatrics. Vol. 39, 3, 1997, ISSN 0041-4301 , pp. 429-432, PMID 9339125 .
↑ Nikolaos Tzemos, Judith Therrien, James Yip, George Thanassoulis, Sonia Tremblay, Michal T. Jamorski, Gary D. Webb, Samuel C. Siu: Outcomes in adults with bicuspid aortic valves. In: Journal of the American Medical Association . Vol. 300, No. 11, 2008, pp. 1317-1325, doi : 10.1001 / jama.300.11.1317 .

[1] Sieglinde Bogensberger include: Hexal Taschenlexikon medicine. = Pocket dictionary medicine. 3rd, revised and expanded edition. Elsevier, Urban & Fischer, Munich et al. 2004, ISBN 3-437-15011-1 , p. 82 .

[2] Bi | kus | pi | da | li | ity. In: Roche Lexicon Medicine. 5th edition. Urban & Fischer, Munich et al. 2003, ISBN 3-437-15170-3 .

[Garg-3] Vidu Garg, Alecia N. Muth, Joshua F. Ransom, Marie K. Schluterman, Robert Barnes, Isabelle N. King, Paul D. Grossfeld, Deepak Srivastava: Mutations in NOTCH1 cause aortic valve disease. In: Nature . Vol. 437, No. 7056, 2005, pp. 270-274, PMID 16025100 , doi : 10.1038 / nature03940 .

[4] Ali Sarigül, Yurdakul Yurdakul, Selim Isbir, Sükrü Mercan, Alpay Celiker: Bicuspid aortic valve and coarctation of aorta. In: The Turkish Journal of Pediatrics. Vol. 39, 3, 1997, ISSN 0041-4301 , pp. 429-432, PMID 9339125 .

[Tzemos-5] Nikolaos Tzemos, Judith Therrien, James Yip, George Thanassoulis, Sonia Tremblay, Michal T. Jamorski, Gary D. Webb, Samuel C. Siu: Outcomes in adults with bicuspid aortic valves. In: Journal of the American Medical Association . Vol. 300, No. 11, 2008, pp. 1317-1325, doi : 10.1001 / jama.300.11.1317 .