Birbeck granule

Birbeck granules of various shapes

A Birbeck granule (synonym Birbeck body , plural Birbeck granula ) is a cell organelle that is typical of Langerhans cells .

properties

Birbeck granules are rod-shaped, sometimes tennis racket-shaped, striped structures in the cytosol . They are a typical microscopic finding in Langerhans cell histiocytosis ( histiocytosis X ). Birbeck granules are made up of the antiviral protein Langerin (synonym CD207). After HIV-1 binds to Langerin, the bound virion is stored in the Birbeck granulum and broken down.

history

Birbeck granules were first described in 1961 by Michael Stanley Clive Birbeck .

Web links

Individual evidence

↑ Mc Dermott R, Ziylan U, Spehner D: Birbeck granules are subdomains of endosomal recycling compartment in human epidermal Langerhans cells, which form where Langerin accumulates . In: Mol. Biol. Cell . 13, No. 1, January 2002, pp. 317-35. doi : 10.1091 / mbc.01-06-0300 . PMID 11809842 . PMC 65091 (free full text).
^ N. Romani, BE Clausen, P. Stoitzner: Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin. In: Immunological reviews. Volume 234, number 1, March 2010, pp. 120-141, doi : 10.1111 / j.0105-2896.2009.00886.x , PMID 20193016 , PMC 2907488 (free full text).
↑ Pillow pfennig A, Aït-Yahia S, Clair-Moninot V: Disruption of the langerin / CD207 gene abolishes Birbeck granules without a marked loss of Langerhans cell function . In: Mol. Cell. Biol . 25, No. 1, January 2005, pp. 88-99. doi : 10.1128 / MCB.25.1.88-99.2005 . PMID 15601833 . PMC 538791 (free full text).
^ L. de Witte, A. Nabatov, M. Pion, D. Fluitsma, MA de Jong, T. de Gruijl, V. Piguet, Y. van Kooyk, TB Geijtenbeek: Langerin is a natural barrier to HIV-1 transmission by Langerhans cells. In: Nature medicine. Volume 13, Number 3, March 2007, pp. 367-371, doi : 10.1038 / nm1541 , PMID 17334373 .
↑ MS Birbeck, AS Breathnach, JD Everall: An electron microscopic study of basal melanocytes and high level clear cells (Langerhans cell) in vitiligo. In: J Invest Dermatol. (1961) Vol. 37, pp. 51-64.

[pmid11809842-1] Mc Dermott R, Ziylan U, Spehner D: Birbeck granules are subdomains of endosomal recycling compartment in human epidermal Langerhans cells, which form where Langerin accumulates . In: Mol. Biol. Cell . 13, No. 1, January 2002, pp. 317-35. doi : 10.1091 / mbc.01-06-0300 . PMID 11809842 . PMC 65091 (free full text).

[2] N. Romani, BE Clausen, P. Stoitzner: Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin. In: Immunological reviews. Volume 234, number 1, March 2010, pp. 120-141, doi : 10.1111 / j.0105-2896.2009.00886.x , PMID 20193016 , PMC 2907488 (free full text).

[pmid15601833-3] Pillow pfennig A, Aït-Yahia S, Clair-Moninot V: Disruption of the langerin / CD207 gene abolishes Birbeck granules without a marked loss of Langerhans cell function . In: Mol. Cell. Biol . 25, No. 1, January 2005, pp. 88-99. doi : 10.1128 / MCB.25.1.88-99.2005 . PMID 15601833 . PMC 538791 (free full text).

[4] L. de Witte, A. Nabatov, M. Pion, D. Fluitsma, MA de Jong, T. de Gruijl, V. Piguet, Y. van Kooyk, TB Geijtenbeek: Langerin is a natural barrier to HIV-1 transmission by Langerhans cells. In: Nature medicine. Volume 13, Number 3, March 2007, pp. 367-371, doi : 10.1038 / nm1541 , PMID 17334373 .

[5] MS Birbeck, AS Breathnach, JD Everall: An electron microscopic study of basal melanocytes and high level clear cells (Langerhans cell) in vitiligo. In: J Invest Dermatol. (1961) Vol. 37, pp. 51-64.